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微流控技术在液体活检临床常规应用中的进展。

Advances in Microfluidics for the Implementation of Liquid Biopsy in Clinical Routine.

机构信息

International Iberian Nanotechnology Laboratory, Braga, Portugal.

Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.

出版信息

Adv Exp Med Biol. 2022;1379:553-590. doi: 10.1007/978-3-031-04039-9_22.

Abstract

In recent years, we have seen major advances in the field of liquid biopsy and its implementation in the clinic, mainly driven by breakthrough developments in the area of molecular biology. New developments have seen an integration of microfluidics and also biosensors in liquid biopsy systems, bringing advantages in terms of cost, sensitivity and automation. Without a doubt, the next decade will bring the clinical validation and approval of these combined solutions, which is expected to be crucial for the wide implementation of liquid biopsy systems in clinical routine.

摘要

近年来,我们在液体活检领域取得了重大进展,其在临床上的应用主要得益于分子生物学领域的突破性进展。新的发展使得微流控和生物传感器在液体活检系统中得到了整合,在成本、灵敏度和自动化方面带来了优势。毫无疑问,未来十年将见证这些联合解决方案的临床验证和批准,这对于液体活检系统在临床常规中的广泛应用至关重要。

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