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小儿原发性脾血管肉瘤：一种针对罕见恶性肿瘤的积极多学科肿瘤管理方法。

Pediatric primary splenic angiosarcoma: an aggressive multidisciplinary approach to the oncologic management of a rare malignancy.

作者信息

Serrano Oscar K, Knapp Esther, Huang Kevin, Baran Galina, Statter Mindy, McClain Danielle, Gill Jonathan

机构信息

Division of Pediatric Surgery, Department of Surgery, Children's Hospital at Montefiore Medical Center, 3415 Bainbridge Avenue, New York, NY 10467, USA.

出版信息

World J Surg Oncol. 2014 Dec 9;12:379. doi: 10.1186/1477-7819-12-379.

DOI:10.1186/1477-7819-12-379
PMID:25487642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4295483/
Abstract

Primary splenic angiosarcoma is an extremely rare and aggressive neoplasm of the vasculature. Uniformly, primary splenic angiosarcoma is a fatal disease despite early diagnosis and treatment. Only patients with localized disease amenable to surgical resection achieve long-term, disease-free survival. We present a review of the literature and report a case of a 3-year-old girl with metastatic primary splenic angiosarcoma who was offered aggressive surgical and medical treatment with curative intent despite her advanced presentation.

摘要

原发性脾血管肉瘤是一种极其罕见且侵袭性强的血管肿瘤。一致的是，原发性脾血管肉瘤是一种致命疾病，尽管能早期诊断和治疗。只有局限性疾病且适合手术切除的患者才能实现长期无病生存。我们对文献进行了综述，并报告了一例3岁转移性原发性脾血管肉瘤女孩的病例，尽管其病情已属晚期，但仍对其进行了积极的手术和药物治疗，以期治愈。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/fdad3575bc05/12957_2014_1851_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/d9b1ba7f5392/12957_2014_1851_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/1d20d1027df9/12957_2014_1851_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/ccb919de8149/12957_2014_1851_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/22c862d59e56/12957_2014_1851_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/35fe6fa57d3d/12957_2014_1851_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/fdad3575bc05/12957_2014_1851_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/d9b1ba7f5392/12957_2014_1851_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/1d20d1027df9/12957_2014_1851_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/ccb919de8149/12957_2014_1851_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/22c862d59e56/12957_2014_1851_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/35fe6fa57d3d/12957_2014_1851_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ee5/4295483/fdad3575bc05/12957_2014_1851_Fig6_HTML.jpg

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Primary splenic angiosarcoma with liver metastasis: A case report and literature review.

本文引用的文献

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Gemcitabine and docetaxel (GEMDOX) for the treatment of relapsed and refractory pediatric sarcomas.吉西他滨联合多西他赛（GEMDOX）治疗复发/难治性儿童肉瘤。
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Primary splenic angiosarcoma.原发性脾血管肉瘤
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Update on gemcitabine and docetaxel combination therapy for primary and metastatic sarcomas.吉西他滨联合多西他赛治疗原发性和转移性肉瘤的最新进展。
原发性脾血管肉瘤伴肝转移：一例报告及文献复习
World J Gastroenterol. 2016 Mar 28;22(12):3506-10. doi: 10.3748/wjg.v22.i12.3506.
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Treatment of relapsed/refractory pediatric sarcomas with gemcitabine and docetaxel.吉西他滨和多西他赛治疗复发/难治性小儿肉瘤
J Pediatr Hematol Oncol. 2009 Oct;31(10):723-9. doi: 10.1097/MPH.0b013e3181b2598c.
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Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study.每周一次紫杉醇治疗不可切除血管肉瘤的II期试验：ANGIOTAX研究
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Primary angiosarcoma of the spleen.脾脏原发性血管肉瘤
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Primary angiosarcoma of the spleen in a child with long-term survival.一名长期存活的儿童脾脏原发性血管肉瘤
Pediatr Surg Int. 2007 Aug;23(8):807-10. doi: 10.1007/s00383-007-1874-1. Epub 2007 Feb 15.
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Randomized phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002 [corrected].吉西他滨与多西他赛联合用药对比吉西他滨单药治疗转移性软组织肉瘤患者的随机II期研究：肉瘤协作研究联盟002研究结果[校正后]
J Clin Oncol. 2007 Jul 1;25(19):2755-63. doi: 10.1200/JCO.2006.10.4117.
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Metastasized angiosarcoma of the spleen in a 2-year-old girl.一名2岁女童的脾脏转移性血管肉瘤
Pediatr Hematol Oncol. 2005 Jul-Aug;22(5):387-90. doi: 10.1080/08880010590964228.
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From the archives of the AFIP: primary vascular neoplasms of the spleen: radiologic-pathologic correlation.源自武装部队病理研究所档案：脾脏原发性血管肿瘤的影像学与病理对照研究
Radiographics. 2004 Jul-Aug;24(4):1137-63. doi: 10.1148/rg.244045006.