Teras Lauren R, Rollison Dana E, Pawlita Michael, Michel Angelika, Blase Jennifer L, Willhauck-Fleckenstein Martina, Gapstur Susan M
Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
Cancer Epidemiol Biomarkers Prev. 2015 Feb;24(2):477-80. doi: 10.1158/1055-9965.EPI-14-1125. Epub 2014 Dec 8.
Three human polyomaviruses have been classified as probable (Merkel cell polyomavirus) or possible (BK and JC polyomaviruses) carcinogens, but few epidemiologic studies have examined associations between this growing class of viruses and risk of non-Hodgkin lymphoma (NHL).
Associations between polyomavirus antibodies and NHL incidence were examined using data from the American Cancer Society Cancer Prevention Study-II. This nested case-control study included 279 NHL cases and 557 controls. Prediagnostic antibodies to the major capsid protein of polyomaviruses BKV, JCV, MCV, TSV, WUV, KIV, HPy6, and HPy7 were measured by fluorescent bead-based multiplex serology, and associations with NHL were estimated using conditional logistic regression (NHL overall) and unconditional polytomous logistic regression (NHL subtypes).
Although an inverse trend was suggested for TSV antibody levels and NHL risk, the HRs were not statistically significant. There were no other observed associations between polyomaviruses and NHL risk. For NHL subtypes, TSV antibody level above the median was associated with a lower risk of CLL/SLL; however, this association was based on 19 cases in the high antibody group and may be due to chance.
Our results do not support associations of polyomaviruses BKV, JCV, WUV, KIV, HPyV6, HPyv7, MCV, or TSV with risk of NHL.
Human polyomavirus antibody levels do not appear to predict a higher NHL risk in immunocompetent individuals.
三种人类多瘤病毒已被归类为可能的致癌物（默克尔细胞多瘤病毒）或潜在的致癌物（BK和JC多瘤病毒），但很少有流行病学研究探讨这类不断增加的病毒与非霍奇金淋巴瘤（NHL）风险之间的关联。
利用美国癌症协会癌症预防研究II的数据，研究多瘤病毒抗体与NHL发病率之间的关联。这项巢式病例对照研究包括279例NHL病例和557例对照。通过基于荧光微球的多重血清学检测多瘤病毒BKV、JCV、MCV、TSV、WUV、KIV、HPy6和HPy7主要衣壳蛋白的诊断前抗体，并使用条件逻辑回归（总体NHL）和无条件多分类逻辑回归（NHL亚型）估计与NHL的关联。
尽管TSV抗体水平与NHL风险呈反向趋势，但风险比无统计学意义。未观察到多瘤病毒与NHL风险之间的其他关联。对于NHL亚型，TSV抗体水平高于中位数与CLL/SLL风险较低相关；然而，这种关联基于高抗体组中的19例病例，可能是偶然因素导致。
我们的结果不支持多瘤病毒BKV、JCV、WUV、KIV、HPyV6、HPyV7、MCV或TSV与NHL风险之间存在关联。
在免疫功能正常的个体中，人类多瘤病毒抗体水平似乎不能预测更高的NHL风险。
