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[血管升压素对青蛙膀胱壁渗透通透性及其环磷酸腺苷、环磷酸鸟苷和肌醇三磷酸含量的影响]

[Effect of vasopressin on the osmotic permeability of the bladder wall in the frog and its content of cAMP, cGMP and inositol triphosphate].

作者信息

Natochin Iu V, Parnova R G, Reznik L V, Natochin M Iu, Firsov D L

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1989 May;75(5):702-8.

PMID:2548897
Abstract

An increase in the water permeability of the frog urinary bladder due to vasopressin, correlates with an increase of cAMP content in the bladder tissue. The osmotic permeability reached its maximum in 15-20 min. The sharp increase of inositol triphosphate content was observed within 20 sec after vasopressin administration, whereas cGMP content significantly decreased within 5 min. The augmentation of cAMP content seems to lead to a rise in water permeability white inositol triphosphate and cGMP acted, probably, as modulators of the vasopressin effect.

摘要

抗利尿激素引起的青蛙膀胱水渗透性增加，与膀胱组织中cAMP含量的增加相关。渗透渗透性在15 - 20分钟内达到最大值。给予抗利尿激素后20秒内观察到肌醇三磷酸含量急剧增加，而cGMP含量在5分钟内显著下降。cAMP含量的增加似乎导致水渗透性升高，而肌醇三磷酸和cGMP可能作为抗利尿激素作用的调节剂。

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引用本文的文献

1
Vasopressin V1-antagonist increases the hydroosmotic response to arginine vasopressin in frog urinary bladder.血管加压素V1拮抗剂增强青蛙膀胱对精氨酸血管加压素的水渗透反应。
Pflugers Arch. 1992 Jul;421(4):406-8. doi: 10.1007/BF00374234.