[环磷酸腺苷、环磷酸鸟苷和钙离子在抗利尿激素对蛙膀胱细胞作用中的作用比较研究]
[Comparative study of the role of cAMP, cGMP and Ca2+ in the action of the antidiuretic hormone on bladder cells of the frog].
作者信息
Shakhmatova E I, Natochin Iu V
出版信息
Probl Endokrinol (Mosk). 1988 Jul-Aug;34(4):57-60.
PMID:2848236
Abstract
Vasopressin (ADH), forskolin and cAMP raise osmotic pressure of the frog bladder; cGMP does not change the response of cells to cAMP and forskolin action but it increases the ADH effect. Being added from the mucous or serous membranes, Ca channel blocker (fendiline) and calmodulin antagonist (thioridazine) inhibit the water effect of ADH. The results obtained indicate a number of loci where Ca2+ is in ADH-dependent reactions which cause an increase in osmotic permeability.
摘要
血管加压素（抗利尿激素）、福斯可林和环磷酸腺苷（cAMP）可提高蛙膀胱的渗透压；环磷酸鸟苷（cGMP）不会改变细胞对cAMP和福斯可林作用的反应，但会增强抗利尿激素的作用。从黏膜或浆膜添加钙通道阻滞剂（芬地林）和钙调蛋白拮抗剂（硫利达嗪）会抑制抗利尿激素的水效应。所得结果表明，在抗利尿激素依赖性反应中，钙离子存在于多个位点，这些反应会导致渗透通透性增加。
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