Butler Merlin G, Lee Jaehoon, Manzardo Ann M, Gold June-Anne, Miller Jennifer L, Kimonis Virginia, Driscoll Daniel J
Departments of Psychiatry and Behavioral Sciences and Pediatrics, University of Kansas Medical Center, Kansas City, Kansas;
Institute for Measurement, Methodology, Analysis & Policy, Texas Tech University, Lubbock, Texas;
Pediatrics. 2015 Jan;135(1):e126-35. doi: 10.1542/peds.2014-1711. Epub 2014 Dec 8.
The goal of this study was to generate and report standardized growth curves for weight, height, head circumference, and BMI for non-growth hormone-treated white male and female US subjects with Prader-Willi syndrome (PWS) between 3 and 18 years of age and develop standardized growth charts.
Anthropometric measures (N = 133) were obtained according to standard methods from 120 non-growth hormone-treated white subjects (63 males and 57 females) with PWS between 3 and 18 years of age. Standardized growth curves were developed for the third, 10th, 25th, 50th, 75th, 90th, and 97th percentiles by using the LMS method for weight, height, head circumference, and BMI for PWS subjects along with the normative third, 50th, and 97th percentiles from national and international growth data. The LMS smoothing procedure summarized the distribution of the anthropometric variables at each age using three parameters: power of the Box-Cox transformation λ (L), median μ (M) and coefficient of variation δ (S).
Weight, height, head circumference, and BMI standardized growth charts representing 7 percentile ranges were developed from 120 non-growth hormone-treated white male and female US subjects with PWS (age range: 3-18 years) and normative third, 50th, and 97th percentiles from national and international data.
We encourage the use of syndrome-specific growth standards to examine and evaluate subjects with PWS when monitoring growth patterns and determining nutritional and obesity status. These variables can be influenced by culture, individual medical care, diet intervention, and physical activity plans.
本研究的目的是生成并报告3至18岁未接受生长激素治疗的美国普拉德-威利综合征（PWS）白人男性和女性的体重、身高、头围和BMI的标准化生长曲线，并制定标准化生长图表。
按照标准方法，对120名3至18岁未接受生长激素治疗的PWS白人受试者（63名男性和57名女性）进行人体测量（N = 133）。使用LMS方法，为PWS受试者的体重、身高、头围和BMI制定第3、第10、第25、第50、第75、第90和第97百分位数的标准化生长曲线，并结合来自国家和国际生长数据的标准第3、第50和第97百分位数。LMS平滑程序使用三个参数总结了每个年龄的人体测量变量分布：Box-Cox变换的幂λ（L）、中位数μ（M）和变异系数δ（S）。
根据120名3至18岁未接受生长激素治疗的美国PWS白人男性和女性受试者以及国家和国际数据的标准第3、第50和第97百分位数，制定了代表7个百分位数范围的体重、身高、头围和BMI标准化生长图表。
我们鼓励在监测生长模式和确定营养及肥胖状况时，使用特定综合征的生长标准来检查和评估PWS受试者。这些变量可能会受到文化、个体医疗护理、饮食干预和体育活动计划的影响。
