Does vitamin D status correlate with clinical and biochemical features of polycystic ovarysyndrome in high school girls?

BACKGROUND

Prevalence of polycystic ovary syndrome (PCOs) is increasing particularly among the female adolescents and young women. It has been hypothesized that disturbance in calcium and vitamin-D metabolism may affect the symptoms of this syndrome. This study was designed to investigate the relationship between vitamin-D and calcium with metabolic parameters and other characteristics of the PCOs.

METHODS

The study included 192 Iranian girls (16-20 years old), of whom 104 had PCOs and 88 were non-PCOs controls. Serum 25(OH) D and calcium level was measured. Anthropometric components, endocrine, metabolic components and insulin resistance were determined in PCOs subjects.

RESULTS

Mean 25 (OH) D was significantly lower in cases (9.7±4.8) than controls (12.3±11.9) but calcium level did not differ between the two groups (9.3±0.3 vs 9.4±0.4). No significant correlations were found between 25(OH) D levels and lipid profile, FBS, fasting insulin endocrine parameters such as testosterone, free testosterone, FSH, LH, and prolactin.

CONCLUSION

Although hypovitamionos D was common is PCOs but did not correlate with clinical features or complications of obesity and insulin resistance PCO like severity of syndrome between vitamin-D deficiency and its severity with some features and complications of PCOs including obesity, insulin resistance.