Eftekhar Maryam, Mirhashemi Elham Sadat, Molaei Behnaz, Pourmasumi Soheila
Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Obstetrics and Gynecology, Fellowship of Perinatology, Zanjan University of Medical Sciences, Zanjan, Iran.
Arch Endocrinol Metab. 2020 Feb;64(1):11-16. doi: 10.20945/2359-3997000000177. Epub 2019 Sep 30.
Objective The aim of this study was to assess the serum vitamin D level in a retrospective study in women with polycystic ovary syndrome (PCOS), according to the different phenotypes of the disease. Subjects and methods In this retrospective study, the records of 351 infertile women who were diagnosed with PCOS were examined, and 200 of them were enrolled in the study randomly in 4 PCOS phenotypes. Fifty normal ovulatory women with the history of male factor were selected as the control group. Parameters, including age, infertility duration, body mass index (BMI), hormone profile, as well as the serum vitamin D level were compared among the 4 phenotypes, with the P-value ≤ 0.05 considered statistically significant. Results The findings showed a higher serum vitamin D level in the control group than in PCOS patients, which was statistically significant (P < 0.001). In addition, there was no significant difference in the serum vitamin D level among the four phenotypes of PCOS. Conclusions No significant difference was found in the serum vitamin D level of the different phenotypes of PCOS. Further studies with larger sample sizes are recommended to be done to establish the role of the serum vitamin D level in PCOS patients.
目的 本研究旨在通过一项回顾性研究，根据多囊卵巢综合征（PCOS）的不同表型评估女性血清维生素D水平。
对象与方法 在这项回顾性研究中，检查了351例被诊断为PCOS的不孕女性的记录，并将其中200例随机纳入4种PCOS表型的研究。选择50例有男性因素病史的正常排卵女性作为对照组。比较4种表型之间的参数，包括年龄、不孕持续时间、体重指数（BMI）、激素谱以及血清维生素D水平，P值≤0.05被认为具有统计学意义。
结果 研究结果显示，对照组的血清维生素D水平高于PCOS患者，差异具有统计学意义（P < 0.001）。此外，PCOS的四种表型之间血清维生素D水平无显著差异。
结论 PCOS不同表型的血清维生素D水平未发现显著差异。建议进行更大样本量的进一步研究，以确定血清维生素D水平在PCOS患者中的作用。
