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Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.关节软骨细胞中转化生长因子β II型受体基因的缺失导致小鼠出现进行性骨关节炎样表型。
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转化生长因子β信号通路在衰老和骨关节炎关节中的调控及作用

Regulation and Role of TGFβ Signaling Pathway in Aging and Osteoarthritis Joints.

作者信息

Baugé Catherine, Girard Nicolas, Lhuissier Eva, Bazille Celine, Boumediene Karim

机构信息

Normandie Univ, France ; UNICAEN, EA4652 MILPAT, Caen, France.

Normandie Univ, France ; UNICAEN, EA4652 MILPAT, Caen, France ; Service d'Anatomie Pathologique, CHU, Caen, France.

出版信息

Aging Dis. 2013 Dec 17;5(6):394-405. doi: 10.14336/AD.2014.0500394. eCollection 2014 Dec.

DOI:10.14336/AD.2014.0500394
PMID:25489490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4249809/
Abstract

Transforming growth factor beta (TGFβ) is a major signalling pathway in joints. This superfamilly is involved in numerous cellular processes in cartilage. Usually, they are considered to favor chondrocyte differentiation and cartilage repair. However, other studies show also deleterious effects of TGFβ which may induce hypertrophy. This may be explained at least in part by alteration of TGFβ signaling pathways in aging chondrocytes. This review focuses on the functions of TGFβ in joints and the regulation of its signaling mediators (receptors, Smads) during aging and osteoarthritis.

摘要

转化生长因子β（TGFβ）是关节中的主要信号通路。这个超家族参与软骨中的众多细胞过程。通常，它们被认为有利于软骨细胞分化和软骨修复。然而，其他研究也表明TGFβ具有有害作用，可能会诱导肥大。这至少部分可以通过衰老软骨细胞中TGFβ信号通路的改变来解释。这篇综述聚焦于TGFβ在关节中的功能以及在衰老和骨关节炎过程中其信号介质（受体、Smads）的调节。