自噬与多酚在骨关节炎中的作用：关注表观遗传调控。

Autophagy and Polyphenols in Osteoarthritis: A Focus on Epigenetic Regulation.

机构信息

Center of Molecular Biology and Pharmacogenetics, Department of Basic Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco 4811230, Chile.

Department of Preclinical Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco 4811230, Chile.

出版信息

Int J Mol Sci. 2021 Dec 31;23(1):421. doi: 10.3390/ijms23010421.

DOI:10.3390/ijms23010421

PMID:35008847

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8745146/

Abstract

Autophagy is an intracellular mechanism that maintains cellular homeostasis in different tissues. This process declines in cartilage due to aging, which is correlated with osteoarthritis (OA), a multifactorial and degenerative joint disease. Several studies show that microRNAs regulate different steps of autophagy but only a few of them participate in OA. Therefore, epigenetic modifications could represent a therapeutic opportunity during the development of OA. Besides, polyphenols are bioactive components with great potential to counteract diseases, which could reverse altered epigenetic regulation and modify autophagy in cartilage. This review aims to analyze epigenetic mechanisms that are currently associated with autophagy in OA, and to evaluate whether polyphenols are used to reverse the epigenetic alterations generated by aging in the autophagy pathway.

摘要

自噬是一种维持不同组织细胞内稳态的细胞内机制。随着年龄的增长，软骨中的自噬过程会衰退，这与骨关节炎（OA）有关，OA 是一种多因素和退行性关节疾病。多项研究表明 microRNAs 可调节自噬的不同步骤，但只有少数 microRNAs 参与 OA。因此，表观遗传修饰可能是 OA 发展过程中的一个治疗机会。此外，多酚是具有很大潜力对抗疾病的生物活性成分，可逆转异常的表观遗传调控并修饰软骨中的自噬。本综述旨在分析目前与 OA 中自噬相关的表观遗传机制，并评估多酚是否可用于逆转自噬途径中衰老引起的表观遗传改变。