Geier David A, Kern Janet K, Homme Kristin G, Geier Mark R
Department of Research, The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA.
CoMeD, Inc, Silver Spring, MD, USA.
Dose Response. 2017 Mar 16;15(1):1559325817690849. doi: 10.1177/1559325817690849. eCollection 2017 Jan-Mar.
Autism spectrum disorder (ASD), tic disorder (TD), and hyperkinetic syndrome of childhood (attention deficit disorder [ADD]/attention deficit hyperactivity disorder [ADHD]) are disorders recently defined as abnormal connectivity spectrum disorders (ACSDs) because they show a similar pattern of abnormal brain connectivity. This study examines whether these disorders are associated with exposure to thimerosal, a mercury (Hg)-based preservative.
A hypothesis testing case-control study evaluated the Vaccine Safety Datalink for the potential dose-dependent odds ratios (ORs) for diagnoses of ASD, TD, and ADD/ADHD compared to controls, following exposure to Hg from thimerosal-containing type b vaccines administrated within the first 15 months of life. Febrile seizures, cerebral degeneration, and unspecified disorders of metabolism, which are not biologically plausibly linked to thimerosal, were examined as control outcomes.
On a per 25 μg Hg basis, cases diagnosed with ASD (OR = 1.493), TD (OR = 1.428), or ADD/ADHD (OR = 1.503) were significantly ( < .001) more likely than controls to have received increased Hg exposure. Similar relationships were observed when separated by gender. Cases diagnosed with control outcomes were no more likely than controls to have received increased Hg exposure.
The results suggest that Hg exposure from thimerosal is significantly associated with the ACSDs of ASD, TD, and ADD/ADHD.
自闭症谱系障碍（ASD）、抽动障碍（TD）和儿童多动综合征（注意力缺陷障碍[ADD]/注意力缺陷多动障碍[ADHD]）最近被定义为异常连接谱障碍（ACSDs），因为它们表现出相似的大脑异常连接模式。本研究探讨这些障碍是否与硫柳汞（一种基于汞[Hg]的防腐剂）的暴露有关。
一项假设检验病例对照研究评估了疫苗安全数据链，以确定在生命的前15个月内接种含硫柳汞的b型疫苗后，与对照组相比，ASD、TD和ADD/ADHD诊断的潜在剂量依赖性比值比（OR）。将热性惊厥、脑变性和未指定的代谢障碍作为对照结果进行研究，这些疾病在生物学上与硫柳汞没有合理联系。
以每25μg汞为基础，被诊断为ASD（OR = 1.493）、TD（OR = 1.428）或ADD/ADHD（OR = 1.503）的病例比对照组更有可能（<0.001）接受增加的汞暴露。按性别分开时观察到类似的关系。被诊断为对照结果的病例与对照组相比，接受增加汞暴露的可能性并不更高。
结果表明，硫柳汞中的汞暴露与ASD、TD和ADD/ADHD的ACSDs显著相关。
