Jiang Xianxin, Chen Yangqing, Yu Fang, Tang Longhua, Li Mingyu, He Jian-Jun
Opt Lett. 2014 Nov 15;39(22):6363-6. doi: 10.1364/OL.39.006363.
We demonstrate an ultrahigh sensitivity silicon photonic biosensor based on cascaded Mach-Zehnder interferometer (MZI) and ring resonator with the Vernier effect using wavelength interrogation. Experimental results show that the sensitivities reached 2870 nm/RIU and 21,500 nm/RIU for MZI sensor and MZI-ring sensor, respectively. A biosensing application was demonstrated by monitoring the interaction between goat and antigoat immunoglobulin G (IgG) pairs. The measured results show that 1 ng/ml IgG resulted in 0.035 nm and 0.5 nm wavelength shift for MZI sensor and MZI-ring sensor, respectively. This high performance sensor is promising for medical diagnostic applications.
我们展示了一种基于级联马赫-曾德尔干涉仪（MZI）和具有游标效应的环形谐振器的超高灵敏度硅光子生物传感器，采用波长询问法。实验结果表明，MZI传感器和MZI-环形传感器的灵敏度分别达到2870 nm/RIU和21500 nm/RIU。通过监测山羊和抗山羊免疫球蛋白G（IgG）对之间的相互作用，展示了一种生物传感应用。测量结果表明，对于MZI传感器和MZI-环形传感器，1 ng/ml的IgG分别导致0.035 nm和0.5 nm的波长偏移。这种高性能传感器在医学诊断应用中具有广阔前景。
