三联成像系统与血管内内窥镜探头：光学相干断层扫描、荧光成像和超声成像相结合
Trimodality imaging system and intravascular endoscopic probe: combined optical coherence tomography, fluorescence imaging and ultrasound imaging.
作者信息
Liang Shanshan, Ma Teng, Jing Joseph, Li Xiang, Li Jiawen, Shung K Kirk, Zhou Qifa, Zhang Jun, Chen Zhongping
出版信息
Opt Lett. 2014 Dec 1;39(23):6652-5. doi: 10.1364/OL.39.006652.
Abstract
In this Letter, we present a trimodality imaging system and an intravascular endoscopic probe for the detection of early-stage atherosclerotic plaques. The integrated system is able to acquire optical coherence tomography (OCT), fluorescence, and ultrasound images and simultaneously display them in real time. A trimodality intravascular endoscopic probe of 1.2 mm in diameter and 7 mm in length was fabricated based on a dual-modality optical probe that integrates OCT and fluorescence imaging functions and a miniature ultrasound transducer. The probe is capable of rotating at up to 600 rpm. Ex vivo images from rabbit aorta and human coronary arteries showed that this combined system is capable of providing high resolution, deep penetration depth and specific molecular fluorescence contrast simultaneously.
摘要
在本信函中，我们展示了一种用于检测早期动脉粥样硬化斑块的三联成像系统和一种血管内内窥镜探头。该集成系统能够采集光学相干断层扫描（OCT）、荧光和超声图像，并实时同步显示这些图像。基于集成了OCT和荧光成像功能的双模态光学探头以及微型超声换能器，制造了一种直径为1.2毫米、长度为7毫米的三联血管内内窥镜探头。该探头能够以高达600转/分钟的速度旋转。来自兔主动脉和人冠状动脉的离体图像表明，这种组合系统能够同时提供高分辨率、深穿透深度和特定分子荧光对比度。
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