Dalian University of Technology, School of Physics and Optoelectronic Engineering, Ganjingzi District, Dalian City, Liaoning Province, China.
J Biomed Opt. 2012 Jul;17(7):070501. doi: 10.1117/1.JBO.17.7.070501.
We developed a multimodality fluorescence and optical coherence tomography probe based on a double-clad fiber (DCF) combiner. The probe is composed of a DCF combiner, grin lens, and micromotor in the distal end. An integrated swept-source optical coherence tomography and fluorescence intensity imaging system was developed based on the combined probe for the early diagnoses of atherosclerosis. This system is capable of real-time data acquisition and processing as well as image display. For fluorescence imaging, the inflammation of atherosclerosis and necrotic core formed with the annexin V-conjugated Cy5.5 were imaged. Ex vivo imaging of New Zealand white rabbit arteries demonstrated the capability of the combined system.
我们开发了一种基于双包层光纤（DCF）合束器的多模态荧光和光相干断层扫描探头。该探头由 DCF 合束器、微透镜和远端的微型电机组成。我们还开发了一种基于组合探头的集成扫频源光相干断层扫描和荧光强度成像系统，用于动脉粥样硬化的早期诊断。该系统能够实时采集和处理数据以及显示图像。对于荧光成像，我们对与 annexin V 缀合的 Cy5.5 形成的动脉粥样硬化炎症和坏死核心进行了成像。新西兰白兔动脉的离体成像证明了组合系统的能力。
