J Biomed Opt. 2011 Jun;16(6):060505. doi: 10.1117/1.3589097.
We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm which, to our knowledge, is the smallest integrated OCT-US probe reported. Fast data acquisition and processing was implemented for real-time imaging. In vitro OCT and US images of human coronary artery with pathology, as well as in vivo images of normal rabbit abdominal aorta, were obtained using the integrated OCT-US probe to demonstrate its capability.
我们开发了一种用于血管内成像应用的微型集成光相干断层扫描（OCT）超声（US）探测系统。在 OCT 探头中，单模光纤出射的光通过梯度折射率透镜聚焦，然后由探头侧面的直角棱镜反射进入样品。它与一个 35MHz 的PMN-PT 侧视超声换能器结合使用，以获得超声图像。OCT 和超声探头被集成到一个探头中，以同时获得 OCT 和超声图像。集成探头的外径为 0.69mm，据我们所知，这是报道的最小的集成 OCT-US 探头。为了实现实时成像，进行了快速的数据采集和处理。使用集成的 OCT-US 探头获得了带有病理学的人冠状动脉的体外 OCT 和 US 图像，以及正常兔腹主动脉的体内图像，以证明其性能。
