Zeng Ling-Li, Shen Hui, Liu Li, Fang Peng, Liu Yadong, Hu Dewen
aDepartment of Automatic Control, College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan bDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang, Liaoning, People's Republic of China.
Neuroreport. 2015 Jan 21;26(2):57-65. doi: 10.1097/WNR.0000000000000301.
Behavioral evidence suggests functional remission or recovery in nonrefractory depressive disorder after successful antidepressant therapy, but the effect of treatment on brain structures remains unclear. It is possible that some specific structural changes are trait-related, in addition to some state-dependent anatomical regions that could be normalized by medications. In the current study, 32 treatment-naïve nonrefractory depressive disorder patients and 34 matched healthy controls underwent structural MRI scans and a subgroup including 16 patients underwent the second scans after clinical recovery with antidepressant treatment. The statistical analysis of gray matter images showed that the state-dependent regions mainly comprised the key regions within the lateral default, dorsal attention, and frontoparietal networks, whereas the trait-related regions included the medial prefrontal cortex, right anterior insula, thalamus, right parahippocampal gyrus, and right middle occipital gyrus. Moreover, the gray matter changes in the left orbitofrontal cortex, right middle frontal gyrus, left inferior parietal lobule, thalamus, left precentral gyrus, left precuneus, and right middle occipital gyrus were significantly positively correlated with the durations of the current depressive episode. The current findings may not only shed new light on the neuronal effect of antidepressant on depression but also provide potential evidence of the relapse risks for the clinically recovered patients after antidepressant treatment.
行为学证据表明，成功进行抗抑郁治疗后，非难治性抑郁症可实现功能缓解或恢复，但治疗对脑结构的影响仍不明确。除了一些可通过药物恢复正常的状态依赖性解剖区域外，一些特定的结构变化可能与特质有关。在本研究中，32例未经治疗的非难治性抑郁症患者和34例匹配的健康对照者接受了结构磁共振成像扫描，其中16例患者在抗抑郁治疗临床康复后接受了第二次扫描。灰质图像的统计分析表明，状态依赖性区域主要包括外侧默认网络、背侧注意网络和额顶叶网络内的关键区域，而特质相关区域包括内侧前额叶皮质、右侧前岛叶、丘脑、右侧海马旁回和右侧枕中回。此外，左侧眶额皮质、右侧额中回、左侧顶下小叶、丘脑、左侧中央前回、左侧楔前叶和右侧枕中回的灰质变化与当前抑郁发作的持续时间显著正相关。目前的研究结果不仅可能为抗抑郁药对抑郁症的神经元作用提供新的线索，还可能为抗抑郁治疗后临床康复患者的复发风险提供潜在证据。
