Wei Xin, Wang Ying, Tu Luxia, Wan Hongping, Chen Qinkai
Department of Nephrology, The First Affiliated Hospital, Nan Chang University, YongWai street 17#, Nanchang city, Jiangxi province 330006, China.
J Med Case Rep. 2014 Dec 13;8:422. doi: 10.1186/1752-1947-8-422.
In systemic lupus erythematosus, acute kidney injury is usually associated with severe lupus nephritis and rarely associated with other glomerular diseases.
We recently encountered a patient with acute kidney injury that was associated with minimal change disease in systemic lupus erythematosus. A 26-year-old Chinese woman who had a history of systemic lupus erythematosus presented with nephrotic syndrome and acute kidney injury. She fulfilled four of the American College of Rheumatology criteria for the classification of systemic lupus erythematosus. However, a renal biopsy revealed that there were no glomerular abnormalities or deposition of immune complex. Her generalized edema disappeared, and her high serum creatinine level decreased to normal after prednisolone therapy.
Though the relationship between lupus and minimal change disease is still not defined, the possibility of systemic lupus erythematosus combined with minimal change disease must be differentiated in patients with lupus and severe proteinuria.
在系统性红斑狼疮中，急性肾损伤通常与严重的狼疮性肾炎相关，很少与其他肾小球疾病相关。
我们最近遇到一名患有急性肾损伤的患者，该急性肾损伤与系统性红斑狼疮中的微小病变病相关。一名有系统性红斑狼疮病史的26岁中国女性出现肾病综合征和急性肾损伤。她符合美国风湿病学会系统性红斑狼疮分类标准中的四项。然而，肾活检显示没有肾小球异常或免疫复合物沉积。泼尼松龙治疗后，她的全身水肿消失，高血清肌酐水平降至正常。
尽管狼疮与微小病变病之间的关系仍不明确，但在患有狼疮和严重蛋白尿的患者中，必须鉴别系统性红斑狼疮合并微小病变病的可能性。
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