Wang Y T, Chou H H, Chen F F, Chen M J, Chiou Y Y
Department of Pediatrics, National Cheng Kung University Medical Center and College of Medicine, Tainan, Taiwan.
Lupus. 2006;15(4):244-7. doi: 10.1191/0961203306lu2285cr.
A 14-year old girl with lupus erythematosus (LE) who initially showed as discoid lupus and followed with nephrotic syndrome one year later. Concomitant piroxicam and indomethacin were prescribed for her arthritis, which preceded two months before the onset of nephrotic syndrome. Histology from renal biopsy showed minimal-change nephrotic syndrome (MCNS). After continuous treatment for six months, nephrotic syndrome resolved completely and no signs of relapse were noted over 14 years of follow-up. For the children, it is rare to have both LE and MCNS simultaneously; sequela of nonsteroidal anti-inflammatory drugs also seldom results in nephrotic syndrome. Though their relationship is still not defined, the possibility of LE combined with MCNS must be differentiated in patients with lupus and severe proteinuria.
一名14岁红斑狼疮（LE）女孩，最初表现为盘状狼疮，1年后出现肾病综合征。在肾病综合征发作前两个月，她因关节炎服用了吡罗昔康和吲哚美辛。肾活检组织学显示为微小病变肾病综合征（MCNS）。持续治疗6个月后，肾病综合征完全缓解，随访14年未发现复发迹象。对于儿童来说，同时患有LE和MCNS很少见；非甾体抗炎药的后遗症也很少导致肾病综合征。尽管它们之间的关系尚不清楚，但对于狼疮和严重蛋白尿患者，必须鉴别LE合并MCNS的可能性。
