Food and Nutrition Department, Faculty of Pharmaceutical Sciences, São Paulo State University-UNESP , Rodovia Araraquara-Jau km1, Araraquara, SP 14801-902, Brazil.
J Agric Food Chem. 2014 Dec 31;62(52):12576-84. doi: 10.1021/jf5038163. Epub 2014 Dec 15.
Orange juice is a rich source of flavonoids considered beneficial to cardiovascular health in humans. The objective of this study was to analyze the pharmacokinetics of the main flavanone glycosides, hesperidin and narirutin, in humans after the consumption of two styles of orange juice, fresh-squeezed (FOJ) and commercially processed (POJ), differing in their amounts of soluble and insoluble forms of these compounds. Healthy human subjects consumed 11.5 mL/kg body weight of FOJ, and after an interval of 30 days, consumed the same quantity of POJ. The results showed that there were no significant differences in the Tmax of the pharmacokinetic curves for the metabolites of hesperidin and narirutin following the consumption of the two styles of juices, and corrected for differences in doses in the POJ and FOJ, there were also no significant differences in the AUC and Cmax values and percent absorption of these compounds.
橙汁是一种富含类黄酮的饮品，被认为对人类心血管健康有益。本研究的目的是分析人类饮用两种橙汁（鲜榨橙汁（FOJ）和商业加工橙汁（POJ））后，主要类黄酮糖苷橙皮苷和柚皮苷的药代动力学。这两种橙汁在可溶性和不可溶性形式的化合物含量上存在差异。健康的人体受试者摄入 11.5 毫升/千克体重的 FOJ，30 天后，摄入相同量的 POJ。结果表明，两种橙汁的代谢产物药代动力学曲线的 Tmax 没有显著差异，并且在 POJ 和 FOJ 之间进行剂量校正后，这些化合物的 AUC 和 Cmax 值以及吸收率也没有显著差异。
