“嗜肺性”猪冠状病毒实验性感染的致病性
Pathogenicity of experimental infection with 'pneumotropic' porcine coronavirus.
作者信息
O'Toole D, Brown I, Bridges A, Cartwright S F
机构信息
Ministry of Agriculture, Fisheries and Food, Central Veterinary Laboratory, Weybridge, Surrey.
出版信息
Res Vet Sci. 1989 Jul;47(1):23-9. doi: 10.1016/S0034-5288(18)31226-8.
Abstract
Virus localisation and lesions were studied in 14-one-week-old piglets following combined intranasal-oral inoculation with a British isolate of 'pneumotropic' porcine coronavirus (PCV) and were compared with the effects of transmissible gastroenteritis virus (TGEV) infection in five piglets. Unlike TGEV-infected piglets, all PCV-inoculated piglets remained clinically healthy. Seroconversion was detected at seven days after inoculation. Mild bronchointerstitial pneumonia involving terminal airways was consistently present at two days after infection and thereafter. Both PCV and TGEV infected bronchiolar epithelium and alveolar macrophages but, unlike TGEV, replication by PCV in villous enterocytes was limited and did not cause villous atrophy.
摘要
对14只1周龄仔猪经鼻内-口腔联合接种一株英国分离的“嗜肺性”猪冠状病毒（PCV）后进行病毒定位和损伤研究，并与5只感染传染性胃肠炎病毒（TGEV）的仔猪的结果进行比较。与感染TGEV的仔猪不同，所有接种PCV的仔猪临床均保持健康。接种后7天检测到血清转化。感染后2天及之后，终末气道始终存在轻度支气管间质性肺炎。PCV和TGEV均感染细支气管上皮和肺泡巨噬细胞，但与TGEV不同，PCV在绒毛肠上皮细胞中的复制有限，未引起绒毛萎缩。
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