Guo Xingzhi, Tang Peng, Li Xiaoqing, Chong Li, Zhang Xin, Li Rui
a Department of Neurology , Shaanxi Provincial People's Hospital , Xi'an , Shaanxi , China.
Int J Neurosci. 2016;126(3):193-8. doi: 10.3109/00207454.2014.996641. Epub 2015 May 22.
Due to the controversial results in assessment of the association between α-2-Macroglobulin gene (A2M) polymorphisms and Parkinson's disease (PD), we performed a meta-analysis to evaluate the relationship between two A2M variants (rs669 and rs3832852) and PD.
All eligible studies were retrieved in PubMed, Web of Science, Embase and PDGene databases. Data were extracted by two investigators independently. All the four genetic models were used for rs669 and rs3832852.
A total of 877 PD patients and 1296 controls from six studies were included for rs669 polymorphisms. The combined odds ratio (OR) indicated that rs669 polymorphisms were likely associated increased risk of PD only in dominant genetic models (OR = 1.41, CI = 1.03-1.92), especially in Asian subgroup (OR = 1.97, CI = 1.03-3.75). Five studies containing 772 PD patients and 1178 controls were identified for rs3832852 polymorphisms. The result suggested that rs3832852 polymorphisms were not associated with PD in all genetic models.
Our data indicate that the rs669 (A/G) polymorphisms in A2M gene are associated with increased risk in PD. To further validate the association of A2M polymorphisms with PD, more studies with larger samples are required.
由于在评估α-2-巨球蛋白基因（A2M）多态性与帕金森病（PD）之间的关联时结果存在争议，我们进行了一项荟萃分析，以评估两种A2M变体（rs669和rs3832852）与PD之间的关系。
在PubMed、科学网、Embase和PDGene数据库中检索所有符合条件的研究。由两名研究人员独立提取数据。rs669和rs3832852均采用所有四种遗传模型。
rs669多态性纳入了来自六项研究的总共877例PD患者和1296例对照。合并比值比（OR）表明，rs669多态性仅在显性遗传模型中可能与PD风险增加相关（OR = 1.41，CI = 1.03 - 1.92），尤其是在亚洲亚组中（OR = 1.97，CI = 1.03 - 3.75）。rs3832852多态性鉴定出五项研究，包含772例PD患者和1178例对照。结果表明，rs3832852多态性在所有遗传模型中均与PD无关。
我们的数据表明，A2M基因中的rs669（A/G）多态性与PD风险增加相关。为进一步验证A2M多态性与PD的关联，需要更多大样本研究。
