Department of Neurology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Can J Neurol Sci. 2012 Jan;39(1):58-64. doi: 10.1017/s0317167100012695.
Cytokines, which are involved in immunological responses, play and important role in the development and progression of Parkinson's disease (PD). The functional polymorphisms identified in cytokine genes are thought to influence PD risk. However the findings of studies investigating the association between cytokine gene polymorphisms and PD risk are still controversial. Therefore, we conducted a meta-analysis, in order to investigate the potential associations between cytokine gene polymorphisms and PD.
Studies of PD and cytokine polymorphisms were identified by searches of PubMed and PDGene. Pooled analyses were performed to assess the association between cytokine gene polymorphisms and PD.
Our results indicated a positive association of TNFα -1031 CC genotype in overall analysis(CC vs. TT: OR=3.146; 95%CI: 1.631-6.070, p=0.008; CC vs. CT+TT: OR=3.187: 95%CI: 1.657-6.128,p=0.008), and an Asian subgroup, C variant(OR=1.328; 95%CI: 1.053-1.675, p=0.034) also conveyed an increased PD risk as well as CC genotype ( CC vs. TT: OR=3.207; 95%CI: 1.614-6.373, p=0.004; CC vs. CT+TT: OR=3.238; 95%CI: 1.636-6.410, p=0.004). A decreased risk for PD was associated with IL-6-174C allele (OR=0.761; 95%CI: 0.641-0.903, p=0.008) and IL-1RA VNTR 2 allele(OR=0.641; 95%CI: 0.456-0.826 p=0.004). For the polymorphisms of IL-1β C[-511]T, IL-1α C[-889]T , TNFα G[-308]A, and IL-10 G[-1082]A no significant association was found between the gene polymorphisms and PD risk.
Our meta-analysis suggested that gene polymorphisms of TNFα -1031, IL-6-174 and IL-1RA VNTR may be associated with PD risk. However, more large well-designed studies will be necessary to validate our findings.
细胞因子参与免疫反应，在帕金森病（PD）的发展和进展中发挥着重要作用。细胞因子基因中鉴定的功能多态性被认为会影响 PD 风险。然而，研究细胞因子基因多态性与 PD 风险之间关联的研究结果仍存在争议。因此，我们进行了荟萃分析，以研究细胞因子基因多态性与 PD 之间的潜在关联。
通过搜索 PubMed 和 PDGene 来确定 PD 和细胞因子多态性的研究。进行汇总分析以评估细胞因子基因多态性与 PD 之间的关联。
我们的结果表明，TNFα-1031CC 基因型在总体分析中存在阳性关联（CC 与 TT：OR=3.146；95%CI：1.631-6.070，p=0.008；CC 与 CT+TT：OR=3.187：95%CI：1.657-6.128，p=0.008），亚洲亚组中 C 变体（OR=1.328；95%CI：1.053-1.675，p=0.034）和 CC 基因型（CC 与 TT：OR=3.207；95%CI：1.614-6.373，p=0.004；CC 与 CT+TT：OR=3.238；95%CI：1.636-6.410，p=0.004）也增加了 PD 风险。IL-6-174C 等位基因（OR=0.761；95%CI：0.641-0.903，p=0.008）和 IL-1RA VNTR2 等位基因（OR=0.641；95%CI：0.456-0.826 p=0.004）与 PD 风险降低相关。对于 IL-1βC[-511]T、IL-1αC[-889]T、TNFαG[-308]A 和 IL-10G[-1082]A 的多态性，基因多态性与 PD 风险之间没有发现显著关联。
我们的荟萃分析表明，TNFα-1031、IL-6-174 和 IL-1RA VNTR 的基因多态性可能与 PD 风险相关。然而，需要更多大型精心设计的研究来验证我们的发现。
