沙特阿拉伯接受常规妇科检查女性中的人乳头瘤病毒感染率及型别分布
Human papillomavirus prevalence and type distribution among women attending routine gynecological examinations in Saudi Arabia.
作者信息
AlObaid Abdulaziz, Al-Badawi Ismail A, Al-Kadri Hanan, Gopala Kusuma, Kandeil Walid, Quint Wim, Al-Aker Murad, DeAntonio Rodrigo
机构信息
King Fahd Medical City, P.O. Box 59046, Riyadh, 11525, Saudi Arabia.
King Faisal Specialist Hospital & Research Centre, P.O. Box 3354, Riyadh, 11211, MBC-52, Saudi Arabia.
出版信息
BMC Infect Dis. 2014 Dec 14;14:643. doi: 10.1186/s12879-014-0643-8.
BACKGROUND
Cervical cancer (CC) is caused by persistent infection with high-risk (HR) human papillomavirus (HPV) types. In Saudi Arabia which has a population of 6.5 million women over the age of 15 years, approximately 152 new cases of CC are diagnosed and 55 women die from the disease annually. Nevertheless current epidemiological data for HPV in this population are limited. This study evaluated the prevalence and type distribution of HPV and documented the awareness of HPV infection and health-related behavior among Saudi and non-Saudi women attending routine examination.
METHODS
This was an observational, epidemiological cross-sectional study conducted between April 2010 and December 2011 at three hospitals in Saudi Arabia. Cervical samples from women aged ≥15 years, who were attending routine gynecological examinations were collected and tested for HPV-DNA by polymerase chain reaction and typed using the SPF10 DEIA/LiPA25 system. Two questionnaires on health-related behavior and awareness of HPV infection were completed.
RESULTS
A total of 417 women, mean age (standard deviation) 41.9 (±10.4) years, were included in the final analysis, of whom 77% (321/417) were Saudi nationals. HPV-DNA was detected in 9.8% women (41/417, 95% confidence interval [CI]: 7.1-13.1). The prevalence of any HR-HPV by age was: 25-34 years: 3.0%; 35-44 years: 4.5%; 45-54 years: 3.2%; >55 years: 10.9%. The most prevalent HR-HPV-types were: HPV-68/73 (5 cases); HPV-18 (4 cases); HPV-16 (3 cases). The most prevalent low risk (LR) types were HPV-6 (4 cases); HPV-42, HPV-53 and HPV-54 (2 cases each). The prevalence of HPV was higher among non-Saudi nationals vs. Saudi nationals (16.7% vs. 7.8%, P = 0.0234). No statistically significant risk factors were identified: 32.2% (101/314) women were aware of HPV and 89.9% (285/317) showed an interest in HPV vaccination.
CONCLUSION
The overall prevalence of HPV was 9.8% in Saudi Arabia, but was higher in women over 55 years, as well as in non-Saudi nationals. These data provide a reference for public health authorities and may also help in determining future policies for the prevention of CC.
CLINICAL TRIAL REGISTRATION
NCT01213459.
背景
宫颈癌（CC）由高危（HR）型人乳头瘤病毒（HPV）持续感染所致。在沙特阿拉伯，15岁以上女性人口达650万，每年约有152例新确诊的宫颈癌病例，55名女性死于该病。然而，该国目前关于HPV的流行病学数据有限。本研究评估了HPV的患病率和类型分布，并记录了前来接受常规检查的沙特和非沙特女性对HPV感染的认知及健康相关行为。
方法
这是一项于2010年4月至2011年12月在沙特阿拉伯三家医院开展的观察性流行病学横断面研究。收集年龄≥15岁、前来接受常规妇科检查女性的宫颈样本，采用聚合酶链反应检测HPV-DNA，并使用SPF10 DEIA/LiPA25系统进行分型。完成两份关于健康相关行为和HPV感染认知的问卷。
结果
共有417名女性纳入最终分析，平均年龄（标准差）为41.9（±10.4）岁，其中77%（321/417）为沙特公民。9.8%的女性（41/417，95%置信区间[CI]：7.1-13.1）检测到HPV-DNA。按年龄划分的任何HR-HPV患病率为：25-34岁：3.0%；35-44岁：4.5%；45-54岁：3.2%；>55岁：10.9%。最常见的HR-HPV类型为：HPV-68/73（5例）；HPV-18（4例）；HPV-16（3例）。最常见的低风险（LR）类型为HPV-6（4例）；HPV-42、HPV-53和HPV-54（各2例）。非沙特公民中HPV患病率高于沙特公民（16.7%对7.8%，P = 0.0234）。未发现具有统计学意义的风险因素：32.2%（101/314）的女性知晓HPV，89.9%（285/317）表示对HPV疫苗接种感兴趣。
结论
沙特阿拉伯HPV总体患病率为9.8%，但在55岁以上女性以及非沙特公民中更高。这些数据为公共卫生当局提供了参考，也可能有助于确定未来预防宫颈癌的政策。
临床试验注册
NCT01213459。
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