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Mini-BESTest——一种用于轻度至中度帕金森病平衡评估的临床可重复性工具?

The Mini-BESTest--a clinically reproducible tool for balance evaluations in mild to moderate Parkinson's disease?

作者信息

Löfgren Niklas, Lenholm Emma, Conradsson David, Ståhle Agneta, Franzén Erika

机构信息

Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, 23100, SE-14183, Huddinge, Sweden.

Department of Physical Therapy, Karolinska University Hospital, Stockholm, Sweden.

出版信息

BMC Neurol. 2014 Dec 12;14:235. doi: 10.1186/s12883-014-0235-7.

Abstract

BACKGROUND

The Mini-BESTest is a clinical balance test that has shown a high sensitivity in detecting balance impairments in elderly with Parkinson's disease (PD). However, its reproducibility between different raters and between test occasions has yet to be investigated in a clinical context. Moreover, no one has investigated the reproducibility of the Mini-BESTest's subcomponents (i.e. anticipatory postural adjustments; postural responses; sensory orientation and dynamic gait). We aimed to investigate the inter-rater and test-retest reproducibility (reliability as well as agreement) of the Mini-BESTest, as well as its subcomponents, in elderly with mild to moderate PD, performed under conditions assimilating clinical practice.

METHOD

This was an observational measurement study with a test-retest design. Twenty-seven individuals with idiopathic PD (66 - 80 years, mean age: 73; Hoehn & Yahr: 2-3; 1-15 years since diagnosis) were included. Two test administrators, having different experiences with the Mini-BESTest, administered the test individually, in separate rooms in a hospital setting. For the test-retest assessment, all participants returned 7 days after the first test session to perform the Mini-BESTest under similar conditions. Intra-class correlation coefficients (ICC2.1), standard error of measurement (SEMagreement), and smallest real difference (SRD) were analyzed.

RESULTS

The Mini-BESTest showed good reliability for both inter-rater and test-retest reproducibility (ICC = 0.72 and 0.80). Regarding agreement, the measurement error (SRD) was found to be 4.1 points (accounting for 15% of the maximal total score) for inter-rater reproducibility and 3.4 points (12% of the maximal total score) for test-retest reproducibility. The investigation of the Mini-BESTest's subcomponents showed a similar pattern for both inter-rater and test-retest reproducibility, where postural responses had the largest proportional measurement error, and sensory orientation showed the highest agreement.

CONCLUSIONS

Our findings indicate that the Mini-BESTest is able to distinguish between individuals with mild to moderate PD; however, when used in clinical balance assessments, the large measurement error needs to be accounted for.

摘要

背景

Mini-BESTest是一项临床平衡测试,在检测帕金森病(PD)老年患者的平衡障碍方面具有较高的敏感性。然而,在临床环境中,其在不同评估者之间以及不同测试场合之间的可重复性尚未得到研究。此外,尚未有人研究Mini-BESTest各个子成分(即预期姿势调整、姿势反应、感觉定向和动态步态)的可重复性。我们旨在研究在模拟临床实践的条件下,Mini-BESTest及其子成分在轻度至中度PD老年患者中的评估者间和重测可重复性(可靠性以及一致性)。

方法

这是一项采用重测设计的观察性测量研究。纳入了27例特发性PD患者(年龄66 - 80岁,平均年龄:73岁;Hoehn & Yahr分级:2 - 3级;诊断后1 - 15年)。两名对Mini-BESTest有不同经验的测试管理人员在医院环境中的不同房间分别对患者进行测试。对于重测评估,所有参与者在第一次测试 session 7天后返回,在类似条件下进行Mini-BESTest。分析了组内相关系数(ICC2.1)、测量标准误差(SEMagreement)和最小真实差异(SRD)。

结果

Mini-BESTest在评估者间和重测可重复性方面均显示出良好的可靠性(ICC分别为0.72和0.80)。关于一致性,发现评估者间可重复性的测量误差(SRD)为4.1分(占最大总分的15%),重测可重复性的测量误差为3.4分(占最大总分的12%)。对Mini-BESTest子成分的研究显示,评估者间和重测可重复性的模式相似,其中姿势反应的比例测量误差最大,感觉定向的一致性最高。

结论

我们的研究结果表明,Mini-BESTest能够区分轻度至中度PD患者;然而,在临床平衡评估中使用时,需要考虑较大的测量误差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8df/4272769/ab0391235cbd/12883_2014_235_Fig1_HTML.jpg

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