2-Aminoethylarsonic acid as an analogue of ethanolamine phosphate. Endowment of ethanolamine-phosphate cytidylyltransferase with CTP pyrophosphatase activity.
作者信息
Visedo-Gonzalez E, Dixon H B
机构信息
Department of Biochemistry, University of Cambridge, U.K.
出版信息
Biochem J. 1989 May 15;260(1):299-301. doi: 10.1042/bj2600299.
Abstract
2-Aminoethylarsonic acid was tested for its ability to act as a substrate for ethanolamine-phosphate cytidylytransferase as a cytidylyl acceptor in place of ethanolamine phosphate. The expected product, like all mixed anhydrides of arsonic acids, should hydrolyse spontaneously with regeneration of the substrate analogue and CMP formation; such CMP production was observed. The limiting velocity with aminoethylarsonic acid is about 90% that with ethanolamine phosphate, and the Michaelis constant is below 20 mM.
摘要
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2-Aminoethylarsonic acid as an analogue of ethanolamine phosphate. Endowment of ethanolamine-phosphate cytidylyltransferase with CTP pyrophosphatase activity.
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本文引用的文献
1
ADP-arsenate. Formation by submitochondrial particles under phosphorylating conditions.
J Biol Chem. 1981 Jun 25;256(12):5981-3.
2
The arsonomethyl analogue of adenosine 5'-phosphate. An uncoupler of adenylate kinase.
Biochem J. 1984 Aug 1;221(3):829-36. doi: 10.1042/bj2210829.
3
The mechanism of pyrophosphorolysis of RNA by RNA polymerase. Endowment of RNA polymerase with artificial exonuclease activity.
Biochem J. 1984 Dec 1;224(2):645-50. doi: 10.1042/bj2240645.
4
The biosynthesis of the phosphonic analogue of cephalin in tetrahymena.
Biochim Biophys Acta. 1966 Dec 7;125(3):548-62. doi: 10.1016/0005-2760(66)90043-9.
5
[CMP-aminoethylphosphonate: intermediary in the phosphonolipids of the rat liver].
Biochimie. 1973;55(10):1311-2.
6
A carbon-phosphorus bond in nature.
Science. 1969 Apr 4;164(3875):37-42. doi: 10.1126/science.164.3875.37.
7
The effect of NAD+ on the catalytic efficiency of glyceraldehyde-3-phosphate dehydrogenase from rabbit muscle.
Biochim Biophys Acta. 1970 Feb 11;198(2):183-91. doi: 10.1016/0005-2744(70)90050-1.
8
Synthesis of 2-aminoethylarsonic acid. A new synthesis of primary.
Biochem J. 1989 May 15;260(1):295-6. doi: 10.1042/bj2600295.
9
Ethanolaminephosphate cytidylyltransferase. Purification and characterization of the enzyme from rat liver.
J Biol Chem. 1975 Nov 25;250(22):8585-90.
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