Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633N. St. Clair 19th Floor, Chicago, IL 60611, United States; Department of Surgery (Organ Transplantation), Northwestern University Feinberg School of Medicine, 676N. St. Clair 19th Floor, Chicago, IL 60611, United States.
Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633N. St. Clair 19th Floor, Chicago, IL 60611, United States.
Gynecol Oncol. 2015 Feb;136(2):317-22. doi: 10.1016/j.ygyno.2014.12.002. Epub 2014 Dec 8.
This study examined the content validity of the NCCN-FACT Ovarian Symptom Index-18 (NFOSI-18), an advanced ovarian cancer symptom index comprised of symptoms perceived as most important by clinical experts and women with advanced ovarian cancer.
Eighteen women with advanced ovarian cancer completed the NFOSI-18 and participated in cognitive interviews to assess: (a) the understandability of the NFOSI-18; and (b) the things patients have in mind when responding to the item, "I am bothered by side effects of treatment;" and (c) the interpretation patients place on items relating to fatigue and lack of energy. Interviews were recorded and transcribed for qualitative analysis.
All but 2 (89%) participants indicated that each item was clear and understandable and the same proportion (89%) stated they were "very confident" or "confident" about providing accurate answers to all but one item. When responding to the item, "I am bothered by side effects of treatment," fatigue, nausea, and neuropathy constituted the most frequently mentioned concerns. Among the participants who were asked, eight participants responded that "fatigue" and "lack of energy" were the same concept and nine responded they were different. Participants associated "fatigue" with tiredness and associated "lack of energy" with the inability to perform daily tasks and activities.
The findings support the content validity of the NFOSI-18. Item revisions, deletions or additions do not appear warranted. Future research can address the reliability and validity of the NFOSI-18 in clinical research.
本研究旨在检验 NCCN-FACT 卵巢症状指数-18（NFOSI-18）的内容效度，该指数是一种高级卵巢癌症状指数，由临床专家和晚期卵巢癌患者认为最重要的症状组成。
18 名晚期卵巢癌患者完成了 NFOSI-18，并参与了认知访谈，以评估：（a）NFOSI-18 的可理解性；（b）患者在回答“我因治疗副作用而感到困扰”这一项目时的想法；（c）患者对与疲劳和缺乏精力相关项目的解释。访谈进行了录音和转录，以便进行定性分析。
除了 2 人（89%）外，所有参与者都表示每个项目都清晰易懂，同样比例（89%）的人表示他们对除了一个项目外的所有项目都“非常有信心”或“有信心”能够提供准确的答案。在回答“我因治疗副作用而感到困扰”这一项目时，疲劳、恶心和神经病变是最常提到的问题。在被问到的参与者中，有 8 人回答“疲劳”和“缺乏能量”是同一个概念，有 9 人回答它们是不同的。参与者将“疲劳”与疲倦联系起来，将“缺乏能量”与无法完成日常任务和活动联系起来。
研究结果支持 NFOSI-18 的内容效度。似乎不需要对项目进行修订、删除或添加。未来的研究可以解决 NFOSI-18 在临床研究中的可靠性和有效性问题。
