Mohr Sharif B, Gorham Edward D, Garland Cedric F, Grant William B, Garland Frank C, Cuomo Raphael E
Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States; Naval Health Research Center, San Diego, CA, United States.
Deartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States.
J Steroid Biochem Mol Biol. 2015 Apr;148:245-52. doi: 10.1016/j.jsbmb.2014.12.005. Epub 2014 Dec 10.
The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, and incidence rates of multiple myeloma.Methods Associations of latitude and UVB irradiance with age-standardized incidence rates of multiple myeloma were analyzed for 175 countries while controlling for sex-specific obesity prevalence, cigarette consumption, and alcohol consumption using multiple linear regression.Results Incidence rates of multiple myeloma were greater at higher latitudes (R(2) for latitude for males=0.31, p<0.0001; females R(2)=0.27, p<0.0001). In regression models for males (R(2)=0.62, p<0.0001) and females (R(2)=0.51, p<0.0001), UVB irradiance was independently inversely associated with incidence rates.Conclusions Age-adjusted incidence rates of multiple myeloma were higher in countries with lower solar UVB irradiance. Further investigation is warranted in individuals of the association of prediagnostic serum 25(OH)D with risk.
本研究的目的是确定纬度、太阳紫外线B（UVB）辐照度与多发性骨髓瘤发病率之间是否存在负相关。方法 利用多元线性回归分析了175个国家中纬度和UVB辐照度与年龄标准化多发性骨髓瘤发病率之间的关联，并对特定性别的肥胖患病率、香烟消费量和酒精消费量进行了控制。结果 多发性骨髓瘤的发病率在高纬度地区更高（男性纬度的R² = 0.31，p < 0.0001；女性R² = 0.27，p < 0.0001）。在男性（R² = 0.62，p < 0.0001）和女性（R² = 0.51，p < 0.0001）的回归模型中，UVB辐照度与发病率独立呈负相关。结论 太阳UVB辐照度较低的国家中，年龄调整后的多发性骨髓瘤发病率较高。对于诊断前血清25(OH)D与风险的关联，有必要在个体中进行进一步研究。
