Division of Epidemiology, Department of Family and Preventive Medicine, University of California San Diego, La Jolla, 92093-0631, USA.
Am J Prev Med. 2011 Jul;41(1):68-74. doi: 10.1016/j.amepre.2011.04.003.
Recent research has suggested a relationship between vitamin D deficiency and risk of leukemia.
Using data from the UN cancer database, GLOBOCAN, this study will determine whether a relationship exists for latitude and ultraviolet B (UVB) irradiance with incidence rates of leukemia in 175 countries.
Multiple regression was used to analyze the independent association between UVB and age-adjusted incidence rates of leukemia in 139 countries in 2002. This study controlled for dietary data on intake of energy from animal sources and per capita healthcare expenditures. The analyses were performed in 2009.
People residing in the highest-latitude countries had the highest rates of leukemia in both men (R(2)=0.34, p<0.0001) and women (R(2)=0.24, p<0.0001). In men, UVB was independently inversely associated with leukemia incidence rates (p≤0.001), whereas animal energy consumption (p=0.02) and per capita healthcare expenditures (p≤0.0001) were independently positively associated (R(2) for model=0.61, p≤0.0001). In women, UVB adjusted for cloud cover was independently inversely associated with leukemia incidence rates (p≤0.01), whereas animal energy consumption (p≤0.05) and per capita healthcare expenditures (p=0.0002) were independently positively associated (R(2) for model=0.51, p<0.0001).
Countries with low UVB had higher age-adjusted incidence rates of leukemia. This suggests the possibility that low serum 25-hydroxyvitamin D status, because of lower levels of UVB, somehow might predict the development of leukemia.
最近的研究表明，维生素 D 缺乏与白血病风险之间存在关联。
本研究利用来自 UN 癌症数据库 GLOBOCAN 的数据，确定纬度和紫外线 B（UVB）辐射与 175 个国家白血病发病率之间是否存在关系。
使用多元回归分析方法，分析了 2002 年 139 个国家的 UVB 与年龄调整后白血病发病率之间的独立关联。本研究控制了动物来源能量摄入和人均医疗保健支出的饮食数据。分析于 2009 年进行。
在男性（R²=0.34，p<0.0001）和女性（R²=0.24，p<0.0001）中，居住在纬度最高国家的人群白血病发病率最高。在男性中，UVB 与白血病发病率呈独立负相关（p≤0.001），而动物能量摄入（p=0.02）和人均医疗保健支出（p≤0.0001）与白血病发病率呈独立正相关（模型 R²=0.61，p≤0.0001）。在女性中，经云层覆盖调整后的 UVB 与白血病发病率呈独立负相关（p≤0.01），而动物能量摄入（p≤0.05）和人均医疗保健支出（p=0.0002）与白血病发病率呈独立正相关（模型 R²=0.51，p<0.0001）。
UVB 水平较低的国家白血病发病率调整后年龄更高。这表明，由于 UVB 水平较低导致的低血清 25-羟维生素 D 状态可能以某种方式预测白血病的发生。
