Mohr S B, Garland C F, Gorham E D, Grant W B, Garland F C
Department of Family and Preventive Medicine 0631C, University of California San Diego, La Jolla, CA 92093, USA.
J Epidemiol Community Health. 2008 Jan;62(1):69-74. doi: 10.1136/jech.2006.052571.
This study examines whether insufficient ultraviolet B (UVB) irradiance, a marker of vitamin D inadequacy, might contribute to lung cancer incidence.
The association of latitude and UVB irradiance with age-adjusted incidence rates of lung cancer in 111 countries was investigated. Independent associations with UVB irradiance, cloud cover, anthropogenic aerosols, and cigarette smoking, were assessed using multiple regression.
Latitude was positively related to incidence rates in men (R(2) = 0.55, p<0.01) and women (R(2) = 0.36, p<0.01). In men, cigarette consumption (p<0.001) was positively related to risk, whereas UVB irradiance was inversely associated (p = 0.003). There were positive associations with UVB absorbers, in particular cloud cover (p = 0.05) and aerosol optical depth (p = 0.005). The R(2) for the model was 0.78 (p<0.001). UVB irradiance was also inversely associated with incidence rates in women (p = 0.0002), whereas cigarette consumption (p<0.001), total cloud cover (p = 0.02) and aerosol optical depth (p = 0.005) were positively associated. The R(2) for the model was 0.77 (p<0.001).
Lower levels of UVB irradiance were independently associated with higher incidence rates of lung cancer in 111 countries.
本研究探讨维生素D缺乏的一个标志——紫外线B（UVB）辐照度不足是否可能导致肺癌发病率上升。
调查了111个国家的纬度和UVB辐照度与年龄调整后的肺癌发病率之间的关联。使用多元回归评估与UVB辐照度、云量、人为气溶胶和吸烟的独立关联。
纬度与男性发病率呈正相关（R² = 0.55，p<0.01），与女性发病率也呈正相关（R² = 0.36，p<0.01）。在男性中，香烟消费量（p<0.001）与风险呈正相关，而UVB辐照度呈负相关（p = 0.003）。与UVB吸收剂呈正相关，特别是云量（p = 0.05）和气溶胶光学厚度（p = 0.005）。该模型的R²为0.78（p<0.001）。UVB辐照度与女性发病率也呈负相关（p = 0.0002），而香烟消费量（p<0.001）、总云量（p = 0.02）和气溶胶光学厚度（p = 0.005）呈正相关。该模型的R²为0.77（p<0.001）。
在111个国家中，较低水平的UVB辐照度与较高的肺癌发病率独立相关。
