血细胞相关炎症指标与糖尿病视网膜病变的关系：一项Meta分析和系统评价
The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review.
作者信息
Luo Wen-Juan, Zhang Wen-Fang
机构信息
Department of Ophthalmology, Lanzhou University Second Hospital, Lanzhou 730000, Gansu Province, China.
出版信息
Int J Ophthalmol. 2019 Feb 18;12(2):312-323. doi: 10.18240/ijo.2019.02.20. eCollection 2019.
Abstract
AIM
To explore the correlation between several blood cell-associated inflammatory indices including mean platelet volume (MPV), platelet distribution width (PDW), neutrophil to lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), and the presence and severity of diabetic retinopathy (DR).
METHODS
We searched for eligible studies from PubMed, EMBASE, Web of Science and CNKI up to December 13, 2017. Standardized mean difference (SMD) calculated with confidence interval (CI) of 95% was used to estimate the values of those indices.
RESULTS
A total of 31 studies were included in the present Meta-analysis. As compared with type 2 diabetes mellitus (T2DM) patients without DR, the values of MPV, PDW, NLR, and PLR were higher in patients with DR (SMD=0.67; 95%CI: 0.36 to 0.98; SMD=0.51; 95%CI: 0.27 to 0.75; SMD=0.77; 95%CI: 0.49 to 1.05 and SMD=1.18; 95%CI: 0.07 to 2.28). Additionally, it was also observed that MPV was closely correlated with the severity of DR.
CONCLUSION
MPV, PDW, NLR, and PLR could be recommended as diagnostic biomarkers for DR, and MPV could be applied to assess the severity of DR.
摘要
目的
探讨包括平均血小板体积（MPV）、血小板分布宽度（PDW）、中性粒细胞与淋巴细胞比值（NLR）以及血小板与淋巴细胞比值（PLR）在内的几种血细胞相关炎症指标与糖尿病视网膜病变（DR）的存在及严重程度之间的相关性。
方法
我们检索了截至2017年12月13日的PubMed、EMBASE、Web of Science和中国知网中的符合条件的研究。采用计算95%置信区间（CI）的标准化均数差（SMD）来估计这些指标的值。
结果
本Meta分析共纳入31项研究。与无DR的2型糖尿病（T2DM）患者相比，DR患者的MPV、PDW、NLR和PLR值更高（SMD = 0.67；95%CI：0.36至0.98；SMD = 0.51；95%CI：0.27至0.75；SMD = 0.77；95%CI：0.49至1.05；SMD = 1.18；9%CI：0.07至2.28）。此外，还观察到MPV与DR的严重程度密切相关。
结论
MPV、PDW、NLR和PLR可推荐作为DR的诊断生物标志物，且MPV可用于评估DR的严重程度。
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2
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Cardiol Young. 2018 Jun;28(6):832-836. doi: 10.1017/S1047951118000422. Epub 2018 Apr 16.
3
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4
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5
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6
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7
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Psychiatry Res. 2017 Dec;258:177-183. doi: 10.1016/j.psychres.2017.07.050. Epub 2017 Jul 26.
8
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9
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