Aydin Murat, Yilmaz Ahsen, Donma Mustafa Metin, Tulubas Feti, Demirkol Muhammed, Erdogan Murat, Gurel Ahmet
Department of Biochemistry, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey.
Department of Pediatrics, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey.
North Clin Istanb. 2015 Sep 25;2(2):87-91. doi: 10.14744/nci.2015.25238. eCollection 2015.
Obesity is a growing health problem in most of the developed countries. It is associated with many chronic diseases, affecting particularly endocrine and cardiovascular systems. Inflammation plays a key role in pathophysiology of obesity. In this study, we aimed to investigate the inflammation status in obese children using neutrophil/lymphocyte ratio.
In this study 130 obese and 57 healthy children were assessed retrospectively. According to Centers for Disease Control 2000 (CDC) BMI percentiles for childhood and adulthood, 85-95 percentile was considered as overweight and >95 percentile as obese.
Lymphocyte/neutrophil ratios in the obese group were significantly higher compared to those in healthy controls (p=0.03 and p=0.045, respectively). Neutrophil/lymphocyte ratio and CRP level in the obese group were significantly higher compared to those in healthy controls (p=0.02 and p=0.00, respectively). Thrombocyte/lymphocyte ratios were not significantly different between two groups (p=0.156).
It is possible that childhood obesity which has been increasingly prevalent recently triggers the pathogenesis of atherosclerosis during the early years of life. Increased neutrophil/lymphocyte ratio might be associated with the severity of inflammation which plays a role in the early stages of atherosclerosis. Therefore, taking childhood obesity under control using diet and other treatment methods will prevent mortality and morbidity in the elderly.
肥胖在大多数发达国家正成为一个日益严重的健康问题。它与许多慢性疾病相关，尤其影响内分泌和心血管系统。炎症在肥胖的病理生理学中起关键作用。在本研究中，我们旨在使用中性粒细胞/淋巴细胞比率来调查肥胖儿童的炎症状态。
本研究对130名肥胖儿童和57名健康儿童进行了回顾性评估。根据疾病控制中心2000年（CDC）儿童及成人BMI百分位数，85 - 95百分位数被视为超重，>95百分位数被视为肥胖。
肥胖组的淋巴细胞/中性粒细胞比率显著高于健康对照组（分别为p = 0.03和p = 0.045）。肥胖组的中性粒细胞/淋巴细胞比率和CRP水平显著高于健康对照组（分别为p = 0.02和p = 0.00）。两组之间的血小板/淋巴细胞比率无显著差异（p = 0.156）。
近期日益普遍的儿童肥胖可能在生命早期触发动脉粥样硬化的发病机制。中性粒细胞/淋巴细胞比率升高可能与炎症严重程度相关，而炎症在动脉粥样硬化早期起作用。因此，通过饮食和其他治疗方法控制儿童肥胖将预防老年人的死亡率和发病率。
