Giust Sonia, La Sorella Giorgio, Sperni Laura, Strukul Giorgio, Scarso Alessandro
Dipartimento di Scienze Molecolari e Nanosistemi, Università Ca' Foscari di Venezia, Calle Larga S. Marta 2137, 30123, Venezia, Italy.
Chem Commun (Camb). 2015 Jan 31;51(9):1658-61. doi: 10.1039/c4cc08833f.
Encapsulation of a cationic carbodiimide condensing agent within a self-assembled hexameric capsule made of resorcin[4]arene units provides a nano-environment that efficiently steers the substrate selectivity in the amide synthesis reaction between carboxylic acids and primary amines. While in solution pairs of acids react similarly with a given amine, in the presence of the capsule the formation of the shorter amide is greatly favored.
将阳离子碳二亚胺缩合剂封装在由间苯二酚[4]芳烃单元构成的自组装六聚体胶囊内，可提供一个纳米环境，该环境能有效控制羧酸与伯胺之间酰胺合成反应中的底物选择性。虽然在溶液中，成对的酸与特定胺的反应相似，但在胶囊存在的情况下，较短链酰胺的形成受到极大促进。
