Jens Sjoerd, Marquering Henk A, Koelemay Mark J W, Reekers Jim A
Department of Radiology, Academic Medical Center, Room G1-229, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands,
Cardiovasc Intervent Radiol. 2015 Feb;38(1):201-5. doi: 10.1007/s00270-014-1036-5. Epub 2014 Dec 13.
To study the feasibility of 2D perfusion imaging in critical limb ischemia (CLI).
METHODS/RESULTS: Perfusion angiography is a new technology which was tested in 18 patients with CLI of the foot. A standardized protocol was used with a catheter placed at the mid-part of the popliteal artery, and a total of 9 cc of non-ionic iodinated contrast material was injected at a rate of 3 cc/sec. The technology is based on early cardiology research where iodinated contrast agents were used for imaging of cardiac perfusion. During the first pass of the contrast, there is a significant diffusion of the contrast agents into the interstitial space, particularly for non-ionic and low-molecular-weight compounds.
The original angiography data can be used to make a time-density curve, which represents the actual perfusion of the foot in time. Angiographic perfusion imaging is a post-processing modality for which no extra contrast or radiation is needed. With this technique, it is possible to get more information about the perfusion status and microcirculation of the foot. This is a step toward functional imaging in CLI patients.
研究二维灌注成像在严重肢体缺血（CLI）中的可行性。
方法/结果：灌注血管造影是一项新技术，在18例足部CLI患者中进行了测试。采用标准化方案，将导管置于腘动脉中部，以3 cc/秒的速率共注入9 cc非离子型碘化造影剂。该技术基于早期心脏病学研究，当时碘化造影剂用于心脏灌注成像。在造影剂首次通过期间，造影剂会大量扩散到间质空间，特别是对于非离子型和低分子量化合物。
原始血管造影数据可用于绘制时间-密度曲线，该曲线代表足部随时间的实际灌注情况。血管造影灌注成像是一种后处理方式，无需额外的造影剂或辐射。通过这项技术，可以获得更多关于足部灌注状态和微循环的信息。这是迈向CLI患者功能成像的一步。
