Khuphe Mthulisi, Kazlauciunas Algy, Huscroft Martin, Thornton Paul D
School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK.
Chem Commun (Camb). 2015 Jan 28;51(8):1520-3. doi: 10.1039/c4cc08387c.
The direct grafting of amphiphilic macromolecules by sequential n-carboxyanhydride ring-opening polymerisation (NCA ROP) from a therapeutic initiator enables the formation of monodisperse drug-containing micelles. The subsequent enzyme-mediated hydrolysis of the peptide component permits the programmed release of the encapsulated drug molecules, demonstrating a controlled drug delivery platform that negates any challenging payload loading procedures.
通过顺序的N-羧基酸酐开环聚合（NCA ROP）从治疗性引发剂直接接枝两亲性大分子，能够形成单分散的含药胶束。随后肽组分的酶介导水解允许封装的药物分子进行程序性释放，展示了一种无需任何具有挑战性的有效载荷加载程序的可控药物递送平台。
