De Cata Angelo, Matarangolo Angela, Inglese Michele, Rubino Rosa, Mazzoccoli Gianluigi
Division of Internal Medicine and Rheumatology Unit, Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, FG, Italy.
Division of Internal Medicine and Chronobiology Unit, Department of Medical Sciences, IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza", San Giovanni Rotondo, FG, Italy.
Clin Exp Med. 2016 Feb;16(1):13-20. doi: 10.1007/s10238-014-0330-5. Epub 2014 Dec 14.
Autoimmune diseases are characterized by an insufficiency of immune tolerance and, although treated with a number of useful drugs, may need more unconventional therapeutic strategies for their more severe presentations. Among such unconventional therapeutic approaches, stem cell autograft and allograft have been used, with the aim of stimulating disease remission by modifying the pathogenic mechanisms that induce anomalous responses against self-antigens. Autologous transplantation is performed with the purpose of retuning autoimmune cells, whereas allogeneic transplantation is performed with the purpose of replacing anomalous immune effectors and mediators. In this article, we comprehensively review up-to-date information on the autoimmune diseases for which the transplantation of stem cells is indicated.
自身免疫性疾病的特征是免疫耐受不足，尽管使用了多种有效药物进行治疗，但对于其更严重的表现形式可能需要更非常规的治疗策略。在这些非常规治疗方法中，已采用干细胞自体移植和同种异体移植，目的是通过改变诱导针对自身抗原异常反应的致病机制来刺激疾病缓解。自体移植的目的是使自身免疫细胞恢复正常，而异体移植的目的是替换异常的免疫效应器和介质。在本文中，我们全面综述了有关表明需要进行干细胞移植的自身免疫性疾病的最新信息。
