Wirths S, Bethge W, Henes J C
Abteilung für Onkologie, Hämatologie, klinische Immunologie, Rheumatologie, Pulmologie, Medizinische Klinik der Universität Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland.
Z Rheumatol. 2016 Oct;75(8):780-785. doi: 10.1007/s00393-016-0194-z.
According to experimental animal models and experiences of patients with coexisting autoimmune diseases, allogeneic stem cell transplantation has the potential to reestablish and maintain immunological tolerance. On the other hand, it is associated with significant treatment related mortality and may induce diverse immunological diseases by graft-versus-host reaction. Other than with severe aplastic anemia, it is not an established therapy for autoimmune diseases; it is under investigation in clinical trials and might be considered in severe, refractory immune cytopenia.
根据实验动物模型以及自身免疫性疾病共存患者的经验，异基因干细胞移植有重建和维持免疫耐受的潜力。另一方面，它与显著的治疗相关死亡率相关，并且可能通过移植物抗宿主反应诱发多种免疫性疾病。除了重型再生障碍性贫血外，它并非自身免疫性疾病的既定疗法；它正在临床试验中接受研究，对于严重的难治性免疫性血细胞减少症可能会考虑使用。
