Romieu Anthony
Institut de Chimie Moléculaire de l'Université de Bourgogne, UMR CNRS 6302, Université de Bourgogne, 9, Avenue Alain Savary, 21078 Dijon, France.
Org Biomol Chem. 2015 Feb 7;13(5):1294-306. doi: 10.1039/c4ob02076f.
This review outlines examples that illustrate a recent and highly innovative concept in the field of (bio)molecular sensing, namely the simultaneous multi-analyte detection using "reactive" luminescent probes that are able to produce an optical signal only in response to multiple (bio)chemical inputs and through covalent chemical reactions with target (bio)analytes. Unlike conventional "AND" molecular logic gates based on supramolecular photochemical mechanisms, these unusual "smart" optical (bio)probes are suitable tools to track the rise and fall of a wider range of biologically relevant analytes, in complex media and with higher selectivity. The potential utility of this concept for in vivo molecular imaging and possible solutions to adapt the described luminogenic processes to far-red or NIR emitters are also discussed.
本综述概述了一些示例，这些示例说明了（生物）分子传感领域中一个最新且极具创新性的概念，即使用“反应性”发光探针进行同步多分析物检测，这些探针仅能响应多种（生物）化学输入并通过与目标（生物）分析物的共价化学反应产生光信号。与基于超分子光化学机制的传统“与”门分子逻辑门不同，这些不同寻常的“智能”光学（生物）探针是在复杂介质中以更高选择性追踪更广泛的生物相关分析物增减的合适工具。还讨论了这一概念在体内分子成像方面的潜在用途，以及使所述发光过程适用于远红光或近红外发射体的可能解决方案。
