Katori M, Harada Y, Ueno A, Majima M, Oda T, Kawamura M
Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan.
Dermatologica. 1989;179 Suppl 1:60-3. doi: 10.1159/000248451.
Des-Phe8-Arg9-BK could be detected in the entire course of rat carrageenin pleurisy up to 24 h, together with a reduction of the residual levels of high molecular weight kininogen and prekallikrein. On the basis of this continuous release of bradikinin, prostaglandin E2 was released up to 5 h in the pleural exudate and enhanced the plasma leakage. In rat cardiac infarction, the initial increase in the number of polymorphonuclear leukocytes in the cardiac tissue was accompanied by leukotriene B4 in the tissue and this was followed by the second increase and activation of the complement system.
在大鼠角叉菜胶性胸膜炎长达24小时的整个过程中都能检测到去苯丙氨酸8 - 精氨酸9 - 缓激肽，同时高分子量激肽原和前激肽释放酶的残留水平降低。基于缓激肽的这种持续释放，前列腺素E2在胸膜渗出液中释放长达5小时，并增强了血浆渗漏。在大鼠心肌梗死中，心脏组织中多形核白细胞数量的最初增加伴随着组织中的白三烯B4，随后是补体系统的第二次增加和激活。
