Mascolo N, Pinto A, Capasso F
Departament of Experimental Pharmacology, University of Naples, Italy.
J Pharm Pharmacol. 1988 Apr;40(4):293-5. doi: 10.1111/j.2042-7158.1988.tb05250.x.
Quercetin reduced the concentration of prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) in the pleural exudate induced in rats by 1% carrageenan given intrapleurally. Leucocyte migration in the exudate was also reduced by the flavonoid. Inhibition of eicosanoids and leucocytes in the exudate was dose-related. Quercetin also reduced LTB4 synthesis in cells stimulated with ionophore A23187, either ex-vivo or in-vitro. A similar, though less active, mode of action was found with quercitrin, while apigenin and luteolin reduced leucocyte accumulation and PGE2 formation, but not LTB4-formation.
槲皮素降低了通过向大鼠胸膜腔内注射1%角叉菜胶诱导产生的胸腔渗出液中前列腺素E2（PGE2）和白三烯B4（LTB4）的浓度。该类黄酮还减少了渗出液中的白细胞迁移。对渗出液中类二十烷酸和白细胞的抑制作用与剂量相关。槲皮素还降低了用离子载体A23187刺激的细胞（无论是离体还是体外）中LTB4的合成。槲皮苷也有类似的作用方式，尽管活性较低，而芹菜素和木犀草素减少了白细胞聚集和PGE2的形成，但不影响LTB4的形成。
