AXIN2在肿瘤发生和表观遗传调控中的作用。
The roles of AXIN2 in tumorigenesis and epigenetic regulation.
作者信息
Li Shuang, Wang Chunpeng, Liu Xiaodong, Hua Shucheng, Liu Xin
机构信息
Department of Epidemiology and Statistics, School of Public Health, Jilin University, 1163 Xinmin Street, Changchun, 130021, Jilin, China.
出版信息
Fam Cancer. 2015 Jun;14(2):325-31. doi: 10.1007/s10689-014-9775-7.
AXIN2, an important regulator in Wnt/β-catenin signaling pathway, takes part in regulating cell proliferation, cytometaplasia, migration, apoptosis and other important functions, has showed close relations with the development of liver cancer, colon cancer, lung cancer, breast cancer and so on. The epigenetic regulation provides new insights for further exploring the pathogenesis of tumor. In this paper, the roles of AXIN2 in tumorigenesis, AXIN2 methylation, ubiquitination and siRNA/RNA regulation will be reviewed.
AXIN2是Wnt/β-连环蛋白信号通路中的一个重要调节因子，参与调节细胞增殖、细胞化生、迁移、凋亡等重要功能，已显示出与肝癌、结肠癌、肺癌、乳腺癌等的发生发展密切相关。表观遗传调控为进一步探索肿瘤发病机制提供了新的见解。本文将综述AXIN2在肿瘤发生、AXIN2甲基化、泛素化及小干扰RNA/RNA调控中的作用。
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