S100A2、S100A4、S100A6、S100A7和S100P在人毛囊中的定位。
Localization of S100A2, S100A4, S100A6, S100A7, and S100P in the human hair follicle.
作者信息
Mitoma Chikage, Kohda Futoshi, Mizote Yukihiro, Miake Akira, Ijichi Ayako, Kawahara Saho, Kohno Miki, Sonoyama Hiroko, Mitamura Yasutaka, Kaku Yumiko, Inoue Hiroko, Sasaki Yoshiko, Ohno Fumitaka, Okabe Noriko, Take Nobutoshi, Mizote Mika, Masuda Akiko, Furue Masutaka
出版信息
Fukuoka Igaku Zasshi. 2014 Jul;105(7):148-56.
The hair follicle is a highly differentiated structure. In this study, we examined immunohistological localization of S100A2, S100A4, S100A6, S100A7, and S100P using specific monoclonal antibodies. S100A2 was strongly expressed in the entire outer-root sheath (ORS), but more weakly in cuticle and medulla in the bulb. S100A6, S100A7, and S100P were expressed in the innermost cells of ORS. The cuticular area was weakly positive for S100A2, S100A6, S100A7, and S100P. S100A4 was expressed in dendritic Langerhans cells and melanocytes. Sebaceous cells were variably immunopositive for S100A2, S100A6, and S100A7. A subset of dermal papilla cells expressed S100A4 and S100A6. None of the antibodies labeled the inner-root sheath. The distinct spatiostructural distributions of the S100 family proteins suggest that each protein is differentially involved in the physiological function of normal hair follicles.
毛囊是一种高度分化的结构。在本研究中，我们使用特异性单克隆抗体检测了S100A2、S100A4、S100A6、S100A7和S100P的免疫组织学定位。S100A2在整个外根鞘（ORS）中强烈表达，但在毛球的角质层和髓质中表达较弱。S100A6、S100A7和S100P在ORS的最内层细胞中表达。角质层区域对S100A2、S100A6、S100A7和S100P呈弱阳性。S100A4在树突状朗格汉斯细胞和黑素细胞中表达。皮脂腺细胞对S100A2、S100A6和S100A7呈不同程度的免疫阳性。一部分真皮乳头细胞表达S100A4和S100A6。所有抗体均未标记内根鞘。S100家族蛋白独特的时空结构分布表明，每种蛋白在正常毛囊的生理功能中发挥着不同的作用。
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