Department of Dermatology, Kyushu University, Fukuoka, Japan; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Dermatol Sci. 2013 Jun;70(3):211-9. doi: 10.1016/j.jdermsci.2013.03.002. Epub 2013 Mar 16.
Despite our growing knowledge regarding the biology of S100 family proteins in cancers and internal diseases, limited data are available with their distribution in normal skin and in sweat gland tumors.
To study the expression and distribution pattern of multiple S100 proteins in normal skin and in the tumors of sweat glands.
Immunohistological staining was performed using S100A2, S100A4, S100A6, S100A7, S100A8/9, S100A11, and S100P in 41 cases of various kinds of sweat gland tumors and in 13 cases of normal skin.
In normal skin, S100A2, S100A6, S100A7, and S100P staining were observed in the sweat glands. S100A2 positively stained in the outer layer of the eccrine duct. S100A6 immunolabeling was observed in the secretory portion of the eccrine gland. Myoepithelial cells of the apocrine gland were positive for S100A2 and S100A6. S100A7 was positive in the acrosyringium, ductal, and secretory portions of the eccrine gland and in the inner layer of the apocrine gland. Intense S100P staining was detected in the inner layer of the acrosyringium and eccrine ducts. Langerhans cells and melanocytes showed strong immunoreactivity to S100A4. Extramammary Paget's disease (EMPD) expressed S100A7 and S100P with partial S100A6 and S1004 staining. Eccrine poroma expressed S100A2 and S100A7 with partial labeling with S100A6. Syringoma expressed S100A2, S1007, and S100P. Apocrine hidrocystoma expressed S100A2 with partial S100A6 and S100A7 immunoreactivity. Syringocystadenoma papilliferum expressed S100A2, S100A6, S100A7, and S100P.
S100A2, S100A6, S100A7, and S100P proteins are specifically involved in structure-related distribution and are potentially useful for differential diagnoses of sweat gland tumors.
尽管我们对 S100 家族蛋白在癌症和内部疾病中的生物学特性有了更多的了解，但关于其在正常皮肤和汗腺肿瘤中的分布，相关数据仍然有限。
研究多种 S100 蛋白在正常皮肤和汗腺肿瘤中的表达和分布模式。
采用免疫组织化学染色法检测 41 例各种汗腺肿瘤和 13 例正常皮肤中 S100A2、S100A4、S100A6、S100A7、S100A8/9、S100A11 和 S100P 的表达。
在正常皮肤中，S100A2、S100A6、S100A7 和 S100P 染色可见于汗腺中。S100A2 在小汗腺外分泌部的外层呈阳性染色。S100A6 免疫标记见于大汗腺的分泌部。大汗腺的肌上皮细胞呈 S100A2 和 S100A6 阳性。S100A7 在小汗腺的顶泌汗腺、导管和分泌部以及大汗腺的内层呈阳性。S100P 在小汗腺顶泌汗腺和导管的内层呈强染色。朗格汉斯细胞和黑色素细胞对 S100A4 呈强烈的免疫反应性。乳腺外 Paget 病（EMPD）表达 S100A7 和 S100P，部分表达 S100A6 和 S100A4 染色。大汗腺瘤表达 S100A2 和 S100A7，部分表达 S100A6。汗管瘤表达 S100A2、S1007 和 S100P。大汗腺囊腺瘤表达 S100A2，部分表达 S100A6 和 S100A7 免疫反应性。汗囊腺瘤伴乳头状瘤样分化表达 S100A2、S100A6、S100A7 和 S100P。
S100A2、S100A6、S100A7 和 S100P 蛋白特异性参与结构相关分布，对汗腺肿瘤的鉴别诊断具有潜在的应用价值。
