Meij J T, Lamers J M
Department of Biochemistry I, Erasmus University Rotterdam, The Netherlands.
Mol Cell Biochem. 1989;88(1-2):73-5. doi: 10.1007/BF00223426.
The regulation of and the intracellular events following alpha 1-adrenergic receptor stimulation in the myocardium still remain to be disclosed. The effect of alpha 1-adrenergic stimulation on phosphoinositide breakdown was studied in cultured neonatal rat ventricular myocytes. Phenylephrine (30 microM) stimulated inositolphosphates formation, but only in the presence of 10 mM LiCl this could be measured. The increase was antagonized by prazosin (1 microM) but not by propranolol (1 microM). The variability in proportional distribution of the three inositolphosphates is discussed.
心肌中α1 - 肾上腺素能受体刺激后的调节及细胞内事件仍有待揭示。在培养的新生大鼠心室肌细胞中研究了α1 - 肾上腺素能刺激对磷酸肌醇分解的影响。去氧肾上腺素（30μM）刺激肌醇磷酸的形成，但只有在存在10 mM LiCl的情况下才能检测到。这种增加可被哌唑嗪（1μM）拮抗，但不被普萘洛尔（1μM）拮抗。讨论了三种肌醇磷酸比例分布的变异性。
