Osborne N N, Tobin A B, Ghazi H
Nuffield Laboratory of Ophthalmology, University of Oxford, U.K.
Neurochem Res. 1988 Mar;13(3):177-91. doi: 10.1007/BF00971531.
This essay attempts to summarize some of the best evidence for the role of inositol trisphosphate as a second messenger in signal transduction processes. The following aspects are addressed in the essay: (a) The synthesis of inositol trisphosphate and other inositol lipids, (b) Receptor-phosphatidylinositol bisphosphate phospholipase C coupling and the N-ras protooncogene, (c) Inositol trisphosphate and intracellular calcium, (d) Cell growth and oncogenes, (e) Receptors linked to the phosphatidylinositol cycle, (f) Phototransduction and (g) Interactions between inositol trisphosphate and other second messengers.
本文试图总结关于肌醇三磷酸作为信号转导过程中第二信使作用的一些最佳证据。文中讨论了以下几个方面：(a) 肌醇三磷酸和其他肌醇脂的合成；(b) 受体 - 磷脂酰肌醇二磷酸磷脂酶C偶联与N - ras原癌基因；(c) 肌醇三磷酸与细胞内钙；(d) 细胞生长与癌基因；(e) 与磷脂酰肌醇循环相关的受体；(f) 光转导；以及(g) 肌醇三磷酸与其他第二信使之间的相互作用。
