Zhang Jie, Guo Dan, Zhang Limeng, Li Deping, Deng Baichuan
Guangdong Provincial Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Guangzhou Qingke Biotechnology Co., Ltd., Guangzhou 510000, China.
Animals (Basel). 2024 Dec 17;14(24):3643. doi: 10.3390/ani14243643.
This study aimed to investigate the effects of dietary supplementation with methylsulfonylmethane (MSM) and myo-inositol (MI) on hair quality, fecal microbiota, and metabolome in poodles. Thirty-two adult poodles categorized based on initial body weight and sex were randomly assigned to four groups. These groups (designated the CON, MSM, MI, and MSM + MI groups) received a basal diet, the same diet supplemented with 0.2% MSM + 0% MI, the same diet supplemented with 0% MSM + 0.2% MI, or the same diet supplemented with 0.2% MSM + 0.2% MI, respectively. The study lasted for 65 days. During the entire study period, body weight, average daily weight gain, feed intake, energy intake, and fecal output were normal in all the animals and did not differ significantly among the treatment groups. Hair scale thickness was lower in the MI and MSM + MI groups than in the CON group on Day 65 ( < 0.05). An amino acid analysis of the hair revealed higher sulfur content in the MI and MSM + MI groups on Day 65 than on Day 0 ( < 0.05). Moreover, the poodles in the MSM, MI, and MSM + MI groups presented significantly lower levels of and than did those in the CON group. The relative abundance of was greater in the MSM and MI groups than in the CON group ( < 0.05). The MSM group presented a greater abundance of than the CON group ( < 0.05). Compared with those in the CON and MSM + MI groups, the abundances of and in the MSM group were greater ( < 0.05). The abundances of and were greater ( < 0.05) in the MI group than in the CON and MSM + MI groups. The poodles in the MI group presented significantly greater abundances of , , , and than did poodles in the CON, MSM, and MSM + MI groups. Fecal metabolomics analysis revealed that MSM, MI, and MSM + MI treatment markedly affected carbohydrate metabolism. MSM + MI treatment also influenced lipid metabolism. These findings suggest that dietary supplementation with MSM and MI can improve the hair quality of poodles.
本研究旨在调查日粮中添加甲基磺酰甲烷（MSM）和肌醇（MI）对贵宾犬毛发质量、粪便微生物群和代谢组的影响。根据初始体重和性别将32只成年贵宾犬分为四组。这些组（分别指定为CON、MSM、MI和MSM + MI组）分别接受基础日粮、添加0.2% MSM + 0% MI的相同日粮、添加0% MSM + 0.2% MI的相同日粮或添加0.2% MSM + 0.2% MI的相同日粮。研究持续65天。在整个研究期间，所有动物的体重、平均日增重、采食量、能量摄入量和粪便产量均正常，各处理组之间无显著差异。在第65天，MI组和MSM + MI组的毛鳞片厚度低于CON组（<0.05）。对毛发的氨基酸分析显示，在第65天，MI组和MSM + MI组的硫含量高于第0天（<0.05）。此外，MSM组、MI组和MSM + MI组的贵宾犬的 和 水平显著低于CON组。MSM组和MI组中 的相对丰度高于CON组（<0.05）。MSM组中 的丰度高于CON组（<0.05）。与CON组和MSM + MI组相比，MSM组中 和 的丰度更高（<0.05）。MI组中 和 的丰度高于CON组和MSM + MI组（<0.05）。MI组的贵宾犬中 、 、 和 的丰度显著高于CON组、MSM组和MSM + MI组。粪便代谢组学分析表明，MSM、MI和MSM + MI处理显著影响碳水化合物代谢。MSM + MI处理也影响脂质代谢。这些发现表明，日粮中添加MSM和MI可以改善贵宾犬的毛发质量。
