Salemovic Dubravka, Pesic-Pavlovic Ivana, Jevtovic Djordje, Bojovic Ksenija, Ranin Jovan, Brmbolic Branko, Stanojevic Maja
Infectious and Tropical Diseases University Hospital, Clinical Center Serbia, HIV/AIDS Unit, Belgrade, Serbia.
Virology Department, Clinical Center Serbia, NRL HIV/AIDS, Belgrade, Serbia.
Arch Med Sci. 2017 Apr 1;13(3):652-658. doi: 10.5114/aoms.2017.66022. Epub 2017 Apr 20.
About one quarter of human immunodeficiency virus (HIV) infected persons in Serbia have also been found to be hepatitis C virus (HCV) co-infected. In the general population, HCV genotype 1 has been shown to be the most prevalent one. Here, we present the first study on the distribution of HCV genotypes among HIV/HCV co-infected patients in Serbia, in relation to epidemiological and clinical features.
The study included HIV/HCV co-infected and a group of HCV mono-infected patients in the period 1998-2012, with collection of epidemiological, clinical, and behavioral data using a standardized questionnaire. The HCV genotyping to the level of pure genotype was performed by reverse hybridization.
Intravenous drug use (IDU) was found to be significantly more prevalent among the co-infected patients ( < 0.01). HCV genotype 1 was detected in 87% of patients with mono-infection, compared to 46.3% of patients with co-infection ( < 0.01); genotypes 3 and 4 were significantly more common among co-infected patients (6% and 5%, vs. 27% and 25%, respectively). Multivariate logistic regression confirmed IDU, infection with non-1 HCV genotype and HCV viral load over 5 log to be predictors of HIV co-infection.
The HCV genotypes 3 and 4 were found to be significantly more prevalent among HIV/HCV co-infected patients in Serbia, compared to HCV mono-infected patients, but also more prevalent compared to the European HIV/HCV co-infected cohort. History of IDU represents an independent predictor of HCV genotypes 3 and 4 infection, with important implications for treatment.
在塞尔维亚，约四分之一的人类免疫缺陷病毒（HIV）感染者同时被发现感染了丙型肝炎病毒（HCV）。在普通人群中，HCV 基因型 1 已被证明是最普遍的一种。在此，我们展示了关于塞尔维亚 HIV/HCV 合并感染患者中 HCV 基因型分布的首项研究，以及其与流行病学和临床特征的关系。
该研究纳入了 1998 年至 2012 年期间 HIV/HCV 合并感染患者以及一组 HCV 单一感染患者，通过标准化问卷收集流行病学、临床和行为学数据。采用反向杂交法进行 HCV 基因分型至纯基因型水平。
发现静脉注射吸毒（IDU）在合并感染患者中显著更为普遍（<0.01）。在单一感染患者中，87%检测出 HCV 基因型 1，而合并感染患者中这一比例为 46.3%（<0.01）；基因型 3 和 4 在合并感染患者中显著更为常见（分别为 6%和 5%，而单一感染患者中分别为 27%和 25%）。多因素逻辑回归证实 IDU、非 1 型 HCV 基因型感染以及 HCV 病毒载量超过 5 log 是 HIV 合并感染的预测因素。
与 HCV 单一感染患者相比，在塞尔维亚 HIV/HCV 合并感染患者中，HCV 基因型 3 和 4 显著更为普遍，而且与欧洲 HIV/HCV 合并感染队列相比也更为普遍。IDU 史是 HCV 基因型 3 和 4 感染的独立预测因素，对治疗具有重要意义。
