Centro Hospitalar Lisboa Norte, EPE-Hospital de Santa Maria, Lisbon, Portugal,
Endocr Pathol. 2015 Mar;26(1):33-6. doi: 10.1007/s12022-014-9351-6.
Secondary tumours of the thyroid gland account for 1.25 to 3 % in clinical series and reach 24 % in autopsy series. Chondrosarcoma is a rare malignant mesenchymal tumour of chondrogenic nature; the mesenchymal variant represents less than 3 % of all chondrosarcomas, being therefore extremely rare. A mesenchymal chondrosarcoma metastasis in the thyroid is exceptional; to our knowledge, only three previous cases of chondrosarcoma metastasis in the thyroid have been reported to date but none of such cases corresponded to a mesenchymal chondrosarcoma. We present the first of such a case in a 27-year-old woman with a 4-year history of mesenchymal chondrosarcoma of the sacrum that was treated by surgery and chemotherapy. At the present admission, head and neck computed tomography revealed a well-defined nodule in the thyroid gland. The diagnosis of metastasis from the mesenchymal chondrosarcoma was made in the right lobectomy specimen.
甲状腺的继发肿瘤在临床系列中占 1.25%至 3%，在尸检系列中占 24%。软骨肉瘤是一种罕见的软骨源性恶性间叶肿瘤；间叶型软骨肉瘤占所有软骨肉瘤的不到 3%，因此极为罕见。甲状腺的间叶性软骨肉瘤转移非常罕见；据我们所知，迄今为止仅报道了三例甲状腺软骨肉瘤转移的病例，但这些病例均不属于间叶性软骨肉瘤。我们报告首例发生在一名 27 岁女性中，该女性患有 4 年病史的骶骨间叶性软骨肉瘤，经手术和化疗治疗。本次入院时，头颈部计算机断层扫描显示甲状腺有一个界限清楚的结节。在右叶切除术标本中诊断为间叶性软骨肉瘤转移。
