Shirabe K, Kanematsu T, Utsunomiya T, Furuta T, Yamagata M, Matsumata T, Sugimachi K, Yasumori K, Masuda K
Second Dept. of Surgery, Kyushu University.
Gan To Kagaku Ryoho. 1989 Aug;16(8 Pt 2):2974-7.
From December 1982 to February 1986, selective regional cancer chemotherapy using Lipiodol plus anticancer drug (Lipiodolization) was prescribed for 87 patients with non-resectable hepatocellular carcinoma (HCC). Eight out of 87 cases survived for more than 3 years. The mean age of the 8 long survivors was 52.6. In the liver function, 2 cases were in Child A, 5 cases in Child B, and 1 case in Child C. The largest diameter of HCCs was 5.3 cm, and the number of the tumors was one in 6 cases, two in one case, and three in one case. No vascular invasion was detected on hepatic angiography. These findings suggested that long survivors in lipiodolization are not in far advanced HCCs. For these 8 cases, lipiodolization was repeatedly prescribed from two to 6 times. The largest amount of adriamycin was 192 mg/case. The longest survivor has lived for 5 years and 6 months after first lipiodolization. After lipiodolization, one tumor vanished, and three tumors decreased in size. Although seven tumors increased in size after lipiodolization, the tumor doubling time of seven tumors were 64, 265, 313, 317, 350, and 1943 days (average 539 +/- 639 days). It is possible that lipiodolization remarkably inhibited tumor growth. Nevertheless, in 5 out of 7 cases, the daughter lesions increased in size and number, although the main tumors grew slowly. Lipiodolization was less effective for newly arising daughter lesions than main lesions.
1982年12月至1986年2月，对87例不可切除的肝细胞癌（HCC）患者采用碘化油加抗癌药物进行选择性区域癌症化疗（碘化油栓塞化疗）。87例中有8例存活超过3年。8例长期存活者的平均年龄为52.6岁。肝功能方面，Child A级2例，Child B级5例，Child C级1例。HCC的最大直径为5.3 cm，肿瘤数量为：6例为1个，1例为2个，1例为3个。肝血管造影未发现血管侵犯。这些结果表明，碘化油栓塞化疗的长期存活者并非处于晚期HCC。对于这8例患者，碘化油栓塞化疗重复进行了2至6次。阿霉素的最大用量为192 mg/例。最长存活者在首次碘化油栓塞化疗后已存活5年6个月。碘化油栓塞化疗后，1个肿瘤消失，3个肿瘤缩小。尽管有7个肿瘤在碘化油栓塞化疗后增大，但这7个肿瘤的倍增时间分别为64、265、313、317、350和1943天（平均539±639天）。碘化油栓塞化疗很可能显著抑制了肿瘤生长。然而，在7例中的5例中，尽管主要肿瘤生长缓慢，但子病灶的大小和数量增加。碘化油栓塞化疗对新出现的子病灶的效果不如对主要病灶的效果。
