2005年至2011年印度尼西亚H5N1 2.1分支病毒的抗原变异
Antigenic Variation in H5N1 clade 2.1 Viruses in Indonesia From 2005 to 2011.
作者信息
Setiawaty Vivi, Pratiwi Eka, Pawestri Hana A, Ibrahim Fera, Soebandrio Amin
机构信息
Center for Biomedical and Basic Technology of Health, National Institute of Health Research and Development, Ministry of Health. ; Doctoral Program of Faculty of Medicine, University of Indonesia.
Center for Biomedical and Basic Technology of Health, National Institute of Health Research and Development, Ministry of Health.
出版信息
Virology (Auckl). 2013 Aug 19;4:27-34. doi: 10.4137/VRT.S11754. eCollection 2013.
Influenza A (H5N1) virus, has spread to several countries in the world and has a high mortality rate. Meanwhile, the virus has evolved into several clades. The human influenza A (H5N1) virus circulating in Indonesia is a member of clade 2.1, which is different in antigenicity from other clades of influenza A (H5N1). An analysis of the antigenic variation in the H5 hemagglutinin gene (HA) of the influenza A (H5N1) virus strains circulating in Indonesia has been undertaken. Several position of amino acid mutations, including mutations at positions 35, 53, 141, 145, 163, 174, 183, 184, 189, and 231, have been identified. The mutation Val-174-Iso appears to play an important role in immunogenicity and cross-reactivity with rabbit antisera. This study shows that the evolution of the H5HA antigenic variation of the influenza A (H5N1) virus circulating in Indonesia from 2005 to 2011 may affect the immunogenicity of the virus.
甲型流感病毒（H5N1）已传播至世界上多个国家，且死亡率很高。同时，该病毒已进化为几个分支。在印度尼西亚传播的人类甲型流感病毒（H5N1）属于2.1分支，其抗原性与甲型流感病毒（H5N1）的其他分支不同。已对在印度尼西亚传播的甲型流感病毒（H5N1）毒株的H5血凝素基因（HA）中的抗原变异进行了分析。已确定了几个氨基酸突变位点，包括35、53、141、145、163、174、183、184、189和231位的突变。Val-174-Iso突变似乎在免疫原性以及与兔抗血清的交叉反应中起重要作用。这项研究表明，2005年至2011年在印度尼西亚传播的甲型流感病毒（H5N1）的H5HA抗原变异的演变可能会影响该病毒的免疫原性。
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