MIDA-乙烯基硅烷：选择性交叉偶联反应及其在功能化二苯乙烯合成中的应用。
MIDA-vinylsilanes: selective cross-couplings and applications to the synthesis of functionalized stilbenes.
机构信息
School of Chemistry and Chemical Engineering, Queen's University Belfast , Belfast BT9 5AG, Northern Ireland.
出版信息
Org Lett. 2015 Jan 2;17(1):10-3. doi: 10.1021/ol503065a. Epub 2014 Dec 16.
PMID:25513732
Abstract
A rapid and stereodefined synthesis of MIDA-boryl vinylsilanes has been achieved through the hydrosilylation of an alkynylboronic ester. The E products which contain a silyl and boryl group can be selectively cross-coupled in a two-step bidirectional sequence to provide a rapid and high-yielding synthesis of complex styrenes.
摘要
通过炔基硼酸酯的硅氢化反应，实现了 MIDA-硼基乙烯基硅烷的快速和立体定向合成。含有硅基和硼基的 E 型产物可以通过两步双向交叉偶联选择性地进行反应，从而快速高产地合成复杂的苯乙烯类化合物。
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